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Tbio
PKP4
Plakophilin-4

Protein Summary
Description
Plays a role as a regulator of Rho activity during cytokinesis. May play a role in junctional plaques. Armadillo-like proteins are characterized by a series of armadillo repeats, first defined in the Drosophila 'armadillo' gene product, that are typically 42 to 45 amino acids in length. These proteins can be divided into subfamilies based on their number of repeats, their overall sequence similarity, and the dispersion of the repeats throughout their sequences. Members of the p120(ctn)/plakophilin subfamily of Armadillo-like proteins, including CTNND1, CTNND2, PKP1, PKP2, PKP4, and ARVCF. PKP4 may be a component of desmosomal plaque and other adhesion plaques and is thought to be involved in regulating junctional plaque organization and cadherin function. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000389757
  • ENSP00000374407
  • ENSG00000144283
  • ENST00000389759
  • ENSP00000374409

Symbol
  • p0071
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.96
kinase perturbation
0.95
transcription factor
0.93
transcription factor perturbation
0.91
drug perturbation
0.87


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.17   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 152   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.17   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 152   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (108)
CDH8
Tbio
Novelty:  0.04055999
p_int:  0.999999974
p_ni:  2.6e-8
Score:  0.38
Data Source:  BioPlex,STRINGDB
CDH5
Tbio
Novelty:  0.00072649
p_int:  0.999998964
p_ni:  0.000001035
p_wrong:  1e-9
Score:  0.628
Data Source:  BioPlex,STRINGDB
CTNNA3
Tbio
Novelty:  0.01472452
p_int:  0.999989104
p_ni:  0.000010896
Score:  0.433
Data Source:  BioPlex,STRINGDB
CLEC11A
Tbio
Novelty:  0.03060601
p_int:  0.999921116
p_ni:  0.000078884
Score:  0.187
Data Source:  BioPlex,STRINGDB
APBA3
Tbio
Novelty:  0.05059532
p_int:  0.999898299
p_ni:  0.000101701
Score:  0.175
Data Source:  BioPlex,STRINGDB
TAX1BP3
Tbio
Novelty:  0.01605171
p_int:  0.999850756
p_ni:  0.000149244
Data Source:  BioPlex
PTGER3
Tclin
Family:  GPCR
Novelty:  0.0012681
p_int:  0.989764893
p_ni:  0.010235103
p_wrong:  4e-9
Score:  0.179
Data Source:  BioPlex,STRINGDB
ABTB2
Tdark
Novelty:  0.45729157
p_int:  0.983262135
p_ni:  0.016737865
Data Source:  BioPlex
TACR3
Tchem
Family:  GPCR
Novelty:  0.00351352
p_int:  0.975215999
p_ni:  0.024784001
Data Source:  BioPlex
TMEM52B
Tdark
Novelty:  1.55824039
p_int:  0.956926137
p_ni:  0.043065907
p_wrong:  0.000007957
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Developmental Biology (R-HSA-1266738)

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Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Formation of the cornified envelope
Reactome
Keratinization
Name
Explore in Pharos
Explore in Source
Developmental Biology
Formation of the cornified envelope
Keratinization
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (25)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations (null)
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
biological sex
1
1
1
62.5
educational attainment
1
2
2
42.8
red blood cell density measurement
1
1
1
33.8
diastolic blood pressure
1
1
1
32.3
hemoglobin measurement
1
1
1
30.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
biological sex
1
62.5
educational attainment
2
42.8
red blood cell density measurement
1
33.8
diastolic blood pressure
1
32.3
hemoglobin measurement
1
30.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
plakophilin 4
VGNC:2755
459676
Macaque
plakophilin 4
698576
Mouse
MGI:109281
227937
Rat
RGD:1307840
295625
Dog
plakophilin 4
VGNC:44618
478759
Species
Name
OMA
EggNOG
Inparanoid
Chimp
plakophilin 4
Macaque
plakophilin 4
Mouse
Rat
Dog
plakophilin 4
Publication Statistics
PubMed Score 30.17
PubMed score by year
PubTator Score 22.62
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title