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Tbio
PKP3
Plakophilin-3

Protein Summary
Description
May play a role in junctional plaques. This gene encodes a member of the arm-repeat (armadillo) and plakophilin gene families. Plakophilin proteins contain numerous armadillo repeats, localize to cell desmosomes and nuclei, and participate in linking cadherins to intermediate filaments in the cytoskeleton. This protein may act in cellular desmosome-dependent adhesion and signaling pathways. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000331563
  • ENSP00000331678
  • ENSG00000184363
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.98
protein complex
0.84
protein domain
0.73
transcription factor
0.7
tissue
0.6


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.57   (req: < 5)
Gene RIFs: 25   (req: <= 3)
Antibodies: 257   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.57   (req: >= 5)
Gene RIFs: 25   (req: > 3)
Antibodies: 257   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (119)
GDF5
Tbio
Novelty:  0.00218118
p_int:  0.999734341
p_ni:  0.000265657
p_wrong:  2e-9
Data Source:  BioPlex
KIF3A
Tbio
Novelty:  0.00555124
p_int:  0.999639701
p_ni:  0.000360242
p_wrong:  5.7e-8
Score:  0.26
Data Source:  BioPlex,STRINGDB
RBM24
Tbio
Novelty:  0.04562076
p_int:  0.997821465
p_ni:  0.002177039
p_wrong:  0.000001496
Data Source:  BioPlex
GPBP1
Tbio
Novelty:  0.18802498
p_int:  0.99752887
p_ni:  0.002471123
p_wrong:  7e-9
Data Source:  BioPlex
OAZ3
Tbio
Family:  Enzyme
Novelty:  0.02374168
p_int:  0.996862734
p_ni:  0.003137261
p_wrong:  4e-9
Data Source:  BioPlex
SGO2
Tbio
Novelty:  0.05544423
p_int:  0.995934231
p_ni:  0.004065553
p_wrong:  2.16e-7
Score:  0.181
Data Source:  BioPlex,STRINGDB
FCF1
Tdark
Novelty:  0.04202976
p_int:  0.995918013
p_ni:  0.004081987
Data Source:  BioPlex
MAS1
Tchem
Family:  GPCR
Novelty:  0.0089712
p_int:  0.993381404
p_ni:  0.006613782
p_wrong:  0.000004813
Data Source:  BioPlex
MAPK9
Tchem
Family:  Kinase
Novelty:  0.00267199
p_int:  0.990456727
p_ni:  0.009535677
p_wrong:  0.000007596
Score:  0.15
Data Source:  BioPlex,STRINGDB
CDK15
Tchem
Family:  Kinase
Novelty:  0.3870338
p_int:  0.990101212
p_ni:  0.009894739
p_wrong:  0.00000405
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Formation of the cornified envelope
Reactome
Keratinization
Name
Explore in Pharos
Explore in Source
Developmental Biology
Formation of the cornified envelope
Keratinization
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (24)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
CAFA
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations (null)
No disease associations found
GWAS Traits (31)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
3
3
4
96.7
eosinophil percentage of leukocytes
2
4
4
96.5
monocyte percentage of leukocytes
2
3
4
96.2
leukocyte count
2
3
3
96.2
neutrophil count
3
2
4
95.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
4
96.7
eosinophil percentage of leukocytes
4
96.5
monocyte percentage of leukocytes
4
96.2
leukocyte count
3
96.2
neutrophil count
4
95.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1891830
56460
Rat
RGD:1309133
293619
Dog
plakophilin 3
VGNC:44617
483399
Horse
plakophilin 3 [Source:HGNC Symbol;Acc:HGNC:9025]
Cow
plakophilin 3
VGNC:32951
516247
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
plakophilin 3
Horse
plakophilin 3 [Source:HGNC Symbol;Acc:HGNC:9025]
Cow
plakophilin 3
Publication Statistics
PubMed Score 40.57
PubMed score by year
PubTator Score 30.52
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title