PKN3
Serine/threonine-protein kinase N3
Protein Summary
Contributes to invasiveness in malignant prostate cancer.
- ENST00000291906
- ENSP00000291906
- ENSG00000160447
- PKNBETA
- UTDP4-1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 0.99 | ||
molecular function | 0.93 | ||
histone modification site profile | 0.74 | ||
transcription factor | 0.68 | ||
tissue sample | 0.57 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 21.53 (req: < 5)
Gene RIFs: 5 (req: <= 3)
Antibodies: 161 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 21.53 (req: >= 5)
Gene RIFs: 5 (req: > 3)
Antibodies: 161 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 10
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 3
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
The Dark Kinase Knowledgebase is an an online compendium of knowledge and experimental results of understudied kinases.
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (3)
Protein-Protein Interactions (60)
SKAP1
Family: Enzyme
Novelty: 0.03753848
p_int: 0.999949398
p_ni: 0.000050602
Data Source: BioPlex
PTGER3
Family: GPCR
Novelty: 0.0012681
p_int: 0.999850164
p_ni: 0.000149836
Data Source: BioPlex
ACVR2B
Family: Kinase
Novelty: 0.00555742
p_int: 0.999801269
p_ni: 0.000198731
Data Source: BioPlex
HAVCR2
Novelty: 0.00155885
p_int: 0.999709151
p_ni: 0.000290849
Score: 0.163
Data Source: BioPlex,STRINGDB
RHOA
Family: Enzyme
Novelty: 0.00022204
p_int: 0.999470313
p_ni: 0.000529687
Score: 0.997
Data Source: BioPlex,STRINGDB
MANSC1
Novelty: 0.91681036
p_int: 0.995735525
p_ni: 0.004263251
p_wrong: 0.000001223
Data Source: BioPlex
EFNB3
Novelty: 0.0120367
p_int: 0.993635099
p_ni: 0.005756082
p_wrong: 0.000608819
Data Source: BioPlex
Nearest Tclin Targets
Pathways (55)
Reactome (4)
KEGG (3)
PathwayCommons (2)
WikiPathways (46)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | RHO GTPase Effectors | ||||
Reactome | RHO GTPases activate PKNs | ||||
Reactome | Signal Transduction | ||||
Reactome | Signaling by Rho GTPases | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
RHO GTPase Effectors | ||||
RHO GTPases activate PKNs | ||||
Signal Transduction | ||||
Signaling by Rho GTPases | ||||
Viral Interactions (0)
Gene Ontology Terms (13)
Functions (5)
Components (3)
Processes (5)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Traceable Author Statement (TAS) | ProtInc | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-EC | |||
Disease Associations ()
GWAS Traits (16)
Items per page:
1 – 5 of 16
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
serum gamma-glutamyl transferase measurement | 2 | 2 | 2 | 91.9 | |||||
platelet crit | 2 | 2 | 2 | 89.4 | |||||
sex hormone-binding globulin measurement | 6 | 1 | 6 | 83.3 | |||||
platelet count | 1 | 1 | 1 | 71.6 | |||||
myeloid white cell count | 1 | 1 | 1 | 70.2 | |||||
Items per page:
1 – 5 of 16
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
serum gamma-glutamyl transferase measurement | 2 | 91.9 | |||||
platelet crit | 2 | 89.4 | |||||
sex hormone-binding globulin measurement | 6 | 83.3 | |||||
platelet count | 1 | 71.6 | |||||
myeloid white cell count | 1 | 70.2 | |||||
Find similar targets by:
IDG Resources
Reagents (1)
Data Resources (1)
Chemical Tool
2-(6-methylpyridin-2-yl)-N-(pyridin-4-yl)quinazolin-4-amine
Details:
- ChEBI: 143120
- Provider: UNC-CH
- Activity: 331 nM
- Selectivity: 0.012
Data:
Order Chemical Tool from:
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | protein kinase N3 | VGNC:4822 | 464773 | |||||
Macaque | protein kinase N3 | 717319 | ||||||
Mouse | MGI:2388285 | 263803 | ||||||
Dog | protein kinase N3 | VGNC:44613 | 491313 | |||||
Horse | protein kinase N3 | VGNC:21499 | 100066882 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | protein kinase N3 | |||||
Macaque | protein kinase N3 | |||||
Mouse | ||||||
Dog | protein kinase N3 | |||||
Horse | protein kinase N3 | |||||
Publication Statistics
PubMed Score 21.53
PubMed score by year
PubTator Score 11.48
PubTator score by year
Patents
Patents by year
Related Publications
Text Mined References (20)
GeneRif Annotations (5)
Items per page:
0 of 0
PMID | Year | Title |
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