Tchem PKN3 Serine/threonine-protein kinase N3

Protein Summary

Description

Contributes to invasiveness in malignant prostate cancer.

Uniprot Accession IDs

• Q6P5Z2
• Q9UM03

Gene Name

• PKN3

Ensembl ID

• ENST00000291906
• ENSP00000291906
• ENSG00000160447

Symbol

• PKNBETA
• UTDP4-1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.99
molecular function	0.93
histone modification site profile	0.74
transcription factor	0.68
tissue sample	0.57

Protein Classes

PANTHER Classes

Protein / Transferase / Kinase / Protein Kinase / Non-receptor Serine/threonine Protein Kinase / Serine/threonine-protein Kinase N3

Protein / Transfer/carrier Protein / Serine/threonine-protein Kinase N3

Protein / Calcium-binding Protein / Intracellular Calcium-sensing Protein / Calmodulin / Serine/threonine-protein Kinase N3

Protein / Calcium-binding Protein / Annexin / Serine/threonine-protein Kinase N3

DTO Classes

Protein / Kinase / Protein Kinase / Agc Group / Pkn Family / Serine/threonine-protein Kinase N3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.38   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 161   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.38   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 161   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0