Tchem PKMYT1 Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase

Protein Summary

Description

Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of the CDK1 kinase specifically when CDK1 is complexed to cyclins. Mediates phosphorylation of CDK1 predominantly on 'Thr-14'. Also involved in Golgi fragmentation. May be involved in phosphorylation of CDK1 on 'Tyr-15' to a lesser degree, however tyrosine kinase activity is unclear and may be indirect. May be a downstream target of Notch signaling pathway during eye development. This gene encodes a member of the serine/threonine protein kinase family. The encoded protein is a membrane-associated kinase that negatively regulates the G2/M transition of the cell cycle by phosphorylating and inactivating cyclin-dependent kinase 1. The activity of the encoded protein is regulated by polo-like kinase 1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]

Uniprot Accession IDs

• Q99640
• B3KUN8
• B4DXD4
• D3DUA4
• F8W164
• I3L1V2
• O14731
• Q7LE24
• Q8TCM9

Gene Name

• PKMYT1

Ensembl ID

• ENST00000262300
• ENSP00000262300
• ENSG00000127564
• ENST00000440027
• ENSP00000397739
• ENST00000573944
• ENSP00000459123
• ENST00000574385
• ENSP00000458943
• ENST00000574730
• ENSP00000460868

Symbol

• MYT1
• MYT1
• PPP1R126

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.94
co-expressed gene	0.85
histone modification site profile	0.84
protein domain	0.73
cell type or tissue	0.67

Protein Classes

PANTHER Classes

Protein / Transferase / Kinase / Protein Kinase / Non-receptor Serine/threonine Protein Kinase / Membrane-associated Tyrosine- And Threonine-specific Cdc2-inhibitory Kinase

DTO Classes

Protein / Kinase / Protein Kinase / Other Group / Wee Family / Membrane-associated Tyrosine- And Threonine-specific Cdc2-inhibitory Kinase

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.15   (req: < 5)

Gene RIFs: 23   (req: <= 3)

Antibodies: 467   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.15   (req: >= 5)

Gene RIFs: 23   (req: > 3)

Antibodies: 467   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 7

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2