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Tchem
PKMYT1
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase

Protein Summary
Description
Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of the CDK1 kinase specifically when CDK1 is complexed to cyclins. Mediates phosphorylation of CDK1 predominantly on 'Thr-14'. Also involved in Golgi fragmentation. May be involved in phosphorylation of CDK1 on 'Tyr-15' to a lesser degree, however tyrosine kinase activity is unclear and may be indirect. May be a downstream target of Notch signaling pathway during eye development. This gene encodes a member of the serine/threonine protein kinase family. The encoded protein is a membrane-associated kinase that negatively regulates the G2/M transition of the cell cycle by phosphorylating and inactivating cyclin-dependent kinase 1. The activity of the encoded protein is regulated by polo-like kinase 1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262300
  • ENSP00000262300
  • ENSG00000127564
  • ENST00000440027
  • ENSP00000397739
  • ENST00000573944
  • ENSP00000459123
  • ENST00000574385
  • ENSP00000458943
  • ENST00000574730
  • ENSP00000460868

Symbol
  • MYT1
  • MYT1
  • PPP1R126
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.94
co-expressed gene
0.85
histone modification site profile
0.84
protein domain
0.73
cell type or tissue
0.67


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.28   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 467   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.28   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 467   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 7
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (6)
Dark Kinase Knowledgebase
Thumbnail image for Dark Kinase Knowledgebase
The Dark Kinase Knowledgebase is an an online compendium of knowledge and experimental results of understudied kinases.
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (188)
CCNA2
Tchem
Novelty:  0.00049887
p_int:  0.999999982
p_ni:  1.2e-8
p_wrong:  7e-9
Score:  0.994
Data Source:  BioPlex,STRINGDB
PLIN3
Tbio
Novelty:  0.00975965
p_int:  0.999999745
p_ni:  2.51e-7
p_wrong:  4e-9
Score:  0.332
Data Source:  BioPlex,STRINGDB
CKS1B
Tbio
Family:  Enzyme
Novelty:  0.00766779
p_int:  0.999942997
p_ni:  0.000001343
p_wrong:  0.00005566
Score:  0.928
Data Source:  BioPlex,STRINGDB
CDK1
Tchem
Family:  Kinase
Novelty:  0.00040776
p_int:  0.999934141
p_ni:  0.000065858
Score:  0.996
Data Source:  BioPlex,Reactome,STRINGDB
CKS2
Tbio
Family:  Enzyme
Novelty:  0.02482411
p_int:  0.99985432
p_ni:  0.000145676
p_wrong:  4e-9
Score:  0.925
Data Source:  BioPlex,STRINGDB
TGFA
Tbio
Novelty:  0.00216159
p_int:  0.999401604
p_ni:  0.000091055
p_wrong:  0.000507341
Data Source:  BioPlex
SPINT2
Tbio
Family:  Enzyme
Novelty:  0.0046602
p_int:  0.996498776
p_ni:  0.00035109
p_wrong:  0.003150134
Data Source:  BioPlex
IL4R
Tclin
Novelty:  0.00359183
p_int:  0.984216065
p_ni:  0.009716779
p_wrong:  0.006067156
Score:  0.177
Data Source:  BioPlex,STRINGDB
CCNB1
Tchem
Novelty:  0.0005503
Score:  0.997
Data Source:  Reactome,STRINGDB
CCNB2
Tbio
Novelty:  0.00672914
Score:  0.995
Data Source:  Reactome,STRINGDB
Pathways (26)
Cell Cycle (R-HSA-1640170)

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Find Similar Targets
Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Cell Cycle Checkpoints
Reactome
Cell Cycle, Mitotic
Reactome
Cyclin A/B1/B2 associated events during G2/M transition
Reactome
G2/M Checkpoints
Name
Explore in Pharos
Explore in Source
Cell Cycle
Cell Cycle Checkpoints
Cell Cycle, Mitotic
Cyclin A/B1/B2 associated events during G2/M transition
G2/M Checkpoints
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (20)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HGNC
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
aspartate aminotransferase measurement
1
1
1
53.7
serum alanine aminotransferase measurement
1
1
1
17.2
balding measurement
1
1
1
13.1
sex hormone-binding globulin measurement
1
1
1
6.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
aspartate aminotransferase measurement
1
53.7
serum alanine aminotransferase measurement
1
17.2
balding measurement
1
13.1
sex hormone-binding globulin measurement
1
6.6
Find similar targets by:
IDG Resources
NanoBRET
image for PKMYT1-NanoLuc®
  • Institute:  UNC-CH
  • Authors:  Julie Pickett
  • PI:  Tim Willson
  • Assay ID:  BAO_0010069
  • Endpoint:  fold change
  • Endpoint Detection:  fluorescence intensity
  • Repository:  Synapse
NanoBRET
image for NanoLuc®-fused PKMYT1
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
protein kinase, membrane associated tyrosine/threonine 1
VGNC:13785
467880
Macaque
protein kinase, membrane associated tyrosine/threonine 1
699350
Mouse
MGI:2137630
268930
Rat
RGD:1305434
287101
Dog
protein kinase, membrane associated tyrosine/threonine 1
VGNC:44610
490050
Species
Name
OMA
EggNOG
Inparanoid
Chimp
protein kinase, membrane associated tyrosine/threonine 1
Macaque
protein kinase, membrane associated tyrosine/threonine 1
Mouse
Rat
Dog
protein kinase, membrane associated tyrosine/threonine 1
Publication Statistics
PubMed Score 36.28
PubMed score by year
PubTator Score 18.29
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title