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Tchem
PKM
Pyruvate kinase PKM

Protein Summary
Description
Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. Stimulates POU5F1-mediated transcriptional activation. Plays a general role in caspase independent cell death of tumor cells. The ratio between the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival. This gene encodes a protein involved in glycolysis. The encoded protein is a pyruvate kinase that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate to ADP, generating ATP and pyruvate. This protein has been shown to interact with thyroid hormone and may mediate cellular metabolic effects induced by thyroid hormones. This protein has been found to bind Opa protein, a bacterial outer membrane pr ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000319622
  • ENSP00000320171
  • ENSG00000067225
  • ENST00000335181
  • ENSP00000334983
  • ENST00000449901
  • ENSP00000403365
  • ENST00000565154
  • ENSP00000455901
  • ENST00000565184
  • ENSP00000455736
  • ENST00000568459
  • ENSP00000456970

Symbol
  • OIP3
  • PK2
  • PK3
  • PKM2
  • PK3
  • TCB
  • OIP3
  • PKM2
  • CTHBP
  • THBP1
  • HEL-S-30
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
viral protein
1
virus
1
molecular function
0.99
protein complex
0.98


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1905.09   (req: < 5)
Gene RIFs: 281   (req: <= 3)
Antibodies: 1066   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1905.09   (req: >= 5)
Gene RIFs: 281   (req: > 3)
Antibodies: 1066   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 25
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 16
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1