Protein Summary
Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. Stimulates POU5F1-mediated transcriptional activation. Plays a general role in caspase independent cell death of tumor cells. The ratio between the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival. This gene encodes a protein involved in glycolysis. The encoded protein is a pyruvate kinase that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate to ADP, generating ATP and pyruvate. This protein has been shown to interact with thyroid hormone and may mediate cellular metabolic effects induced by thyroid hormones. This protein has been found to bind Opa protein, a bacterial outer membrane pr ...more
- ENST00000319622
- ENSP00000320171
- ENSG00000067225
- ENST00000335181
- ENSP00000334983
- ENST00000449901
- ENSP00000403365
- ENST00000565154
- ENSP00000455901
- ENST00000565184
- ENSP00000455736
- ENST00000568459
- ENSP00000456970
- OIP3
- PK2
- PK3
- PKM2
- PK3
- TCB
- OIP3
- PKM2
- CTHBP
- THBP1
- HEL-S-30
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
interacting protein | 1 | ||
viral protein | 1 | ||
virus | 1 | ||
molecular function | 0.99 | ||
protein complex | 0.98 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1543.92 (req: < 5)
Gene RIFs: 281 (req: <= 3)
Antibodies: 1066 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1543.92 (req: >= 5)
Gene RIFs: 281 (req: > 3)
Antibodies: 1066 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 25
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 16
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (16)
Protein-Protein Interactions (496)
CYP1A1
Novelty: 0.0002404
p_int: 0.767213419
p_ni: 0.232786581
Score: 0.364
Data Source: BioPlex,STRINGDB
DDX19B
Family: Enzyme
Novelty: 0.0504568
p_int: 0.765904555
p_ni: 0.234095445
Score: 0.19
Data Source: BioPlex,STRINGDB
PAPLN
Novelty: 0.06871524
p_int: 0.756537652
p_ni: 0.243462348
Score: 0.19
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets (7)
Upstream (7)
Pathways (32)
Reactome (7)
KEGG (11)
PathwayCommons (8)
UniProt (1)
WikiPathways (5)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Glucose metabolism | ||||
Reactome | Glycolysis | ||||
Reactome | Immune System | ||||
Reactome | Innate Immune System | ||||
Reactome | Metabolism | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Glucose metabolism | ||||
Glycolysis | ||||
Immune System | ||||
Innate Immune System | ||||
Metabolism | ||||
Viral Interactions (0)
Gene Ontology Terms (39)
Functions (11)
Components (14)
Processes (14)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | CACAO | |||
Inferred from High Throughput Direct Assay (HDA) | BHF-UCL | |||
Inferred from High Throughput Direct Assay (HDA) | UniProtKB | |||
Inferred from High Throughput Direct Assay (HDA) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations ()
GWAS Traits (2)
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
aspartate aminotransferase measurement | 1 | 1 | 0 | 5.9 | 30.2 | ||||
serum alanine aminotransferase measurement | 1 | 1 | 0 | 5.5 | 1.5 | ||||
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
aspartate aminotransferase measurement | 0 | 5.9 | 30.2 | ||||
serum alanine aminotransferase measurement | 0 | 5.5 | 1.5 | ||||
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | pyruvate kinase M1/2 | VGNC:49018 | 748700 | |||||
Macaque | pyruvate kinase M1/2 | 697742 | ||||||
Mouse | MGI:97591 | 18746 | ||||||
Rat | RGD:3337 | 25630 | ||||||
Dog | pyruvate kinase M1/2 | 403874 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | pyruvate kinase M1/2 | |||||
Macaque | pyruvate kinase M1/2 | |||||
Mouse | ||||||
Rat | ||||||
Dog | pyruvate kinase M1/2 | |||||
Publication Statistics
PubMed Score 1543.92
PubMed score by year
PubTator Score 558.71
PubTator score by year
Patents
Patents by year
Related Publications
Text Mined References (340)
GeneRif Annotations (281)
Items per page:
0 of 0
PMID | Year | Title |
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