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Tbio
PKLR
Pyruvate kinase PKLR

Protein Summary
Description
Plays a key role in glycolysis. The protein encoded by this gene is a pyruvate kinase that catalyzes the transphosphorylation of phohsphoenolpyruvate into pyruvate and ATP, which is the rate-limiting step of glycolysis. Defects in this enzyme, due to gene mutations or genetic variations, are the common cause of chronic hereditary nonspherocytic hemolytic anemia (CNSHA or HNSHA). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000342741
  • ENSP00000339933
  • ENSG00000143627
  • ENST00000392414
  • ENSP00000376214
  • ENST00000571194
  • ENSP00000461487
  • ENSG00000262785
  • ENST00000572740
  • ENSP00000459921

Symbol
  • PK1
  • PKL
  • PK1
  • PKL
  • RPK
  • PKRL
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
molecular function
0.95
biological process
0.94
disease perturbation
0.79
disease
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 368.11   (req: < 5)
Gene RIFs: 54   (req: <= 3)
Antibodies: 487   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 368.11   (req: >= 5)
Gene RIFs: 54   (req: > 3)
Antibodies: 487   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (328)
MRAS
Tbio
Family:  Enzyme
Novelty:  0.01544981
p_int:  0.999817905
p_ni:  0.000182083
p_wrong:  1.3e-8
Score:  0.686
Data Source:  BioPlex,STRINGDB
NT5DC1
Tdark
Family:  Enzyme
Novelty:  0.33904133
p_int:  0.99957282
p_ni:  0.000347294
p_wrong:  0.000079885
Score:  0.537
Data Source:  BioPlex,STRINGDB
CYP4B1
Tbio
Novelty:  0.01202804
p_int:  0.998874876
p_ni:  0.001125123
p_wrong:  1e-9
Score:  0.699
Data Source:  BioPlex,STRINGDB
ENO4
Tbio
Family:  Enzyme
Novelty:  0.05411699
Score:  0.987
Data Source:  STRINGDB
ENO3
Tbio
Family:  Enzyme
Novelty:  0.00322051
Score:  0.985
Data Source:  STRINGDB
ENO1
Tchem
Family:  Enzyme
Novelty:  0.00109178
Score:  0.984
Data Source:  STRINGDB
GPI
Tbio
Family:  Enzyme
Novelty:  0.00095404
Score:  0.983
Data Source:  STRINGDB
ENO2
Tbio
Family:  Enzyme
Novelty:  0.00016748
Score:  0.98
Data Source:  STRINGDB
PC
Tbio
Family:  Enzyme
Novelty:  0.00271694
Score:  0.979
Data Source:  STRINGDB
PCK1
Tbio
Family:  Kinase
Novelty:  0.0033726
Score:  0.966
Data Source:  STRINGDB
Nearest Tclin Targets (7)
Explore Nearest Tclin Targets
1 – 5 of 7
GUCY2C
Tclin
Family:  Kinase
KEGG Distance:  1
Common Pathways:  2
RRM1
Tclin
Family:  Enzyme
KEGG Distance:  1
Common Pathways:  2
GUCY1B1
Tclin
Family:  Enzyme
KEGG Distance:  1
Common Pathways:  2
RRM2
Tclin
Family:  Enzyme
KEGG Distance:  1
Common Pathways:  2
NPR1
Tclin
Family:  Kinase
KEGG Distance:  1
Common Pathways:  2
Pathways (29)
ChREBP activates metabolic gene expression (R-HSA-163765)

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Find Similar Targets
Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ChREBP activates metabolic gene expression
Reactome
Developmental Biology
Reactome
Glucose metabolism
Reactome
Glycolysis
Reactome
Integration of energy metabolism
Name
Explore in Pharos
Explore in Source
ChREBP activates metabolic gene expression
Developmental Biology
Glucose metabolism
Glycolysis
Integration of energy metabolism
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (18)
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Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (62)
Items per page:
1 – 5 of 62
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
3
2
4
93.8
reticulocyte measurement
3
2
4
93.8
cancer antigen 15.3 measurement
1
2
2
93.8
cancer antigen 15.3 measurement
1
2
2
93.8
3
3
0
1.3
93.3
Items per page:
1 – 5 of 62
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
4
93.8
reticulocyte measurement
4
93.8
cancer antigen 15.3 measurement
2
93.8
cancer antigen 15.3 measurement
2
93.8
0
1.3
93.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
pyruvate kinase L/R
VGNC:48991
469513
Macaque
pyruvate kinase L/R
719152
Mouse
MGI:97604
18770
Rat
RGD:3336
24651
Dog
pyruvate kinase L/R
VGNC:44609
490425
Species
Name
OMA
EggNOG
Inparanoid
Chimp
pyruvate kinase L/R
Macaque
pyruvate kinase L/R
Mouse
Rat
Dog
pyruvate kinase L/R
Publication Statistics
PubMed Score 368.11
PubMed score by year
PubTator Score 220.33
PubTator score by year
Patents
Patents by year
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Related Publications
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PMID
Year
Title