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Tbio
PKDCC
Extracellular tyrosine-protein kinase PKDCC

Protein Summary
Description
Secreted tyrosine-protein kinase that mediates phosphorylation of extracellular proteins and endogenous proteins in the secretory pathway, which is essential for patterning at organogenesis stages. Mediates phosphorylation of MMP1, MMP13, MMP14, MMP19 and ERP29 (PubMed:25171405). Probably plays a role in platelets: rapidly and quantitatively secreted from platelets in response to stimulation of platelet degranulation (PubMed:25171405). May also have serine/threonine protein kinase activity. Required for longitudinal bone growth through regulation of chondrocyte differentiation. May be indirectly involved in protein transport from the Golgi apparatus to the plasma membrane (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000294964
  • ENSP00000294964
  • ENSG00000162878

Symbol
  • SGK493
  • VLK
  • Vlk
  • SGK493
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.91
transcription factor
0.78
biological process
0.74
transcription factor binding site profile
0.66
transcription factor perturbation
0.61


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.56   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 61   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.56   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 61   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (61)
POMK
Tbio
Family:  Kinase
Novelty:  0.09340344
p_int:  0.999998465
p_ni:  4.92e-7
p_wrong:  0.000001043
Score:  0.637
Data Source:  BioPlex,STRINGDB
FREM1
Tbio
Novelty:  0.0333243
Score:  0.698
Data Source:  STRINGDB
PDE5A
Tclin
Family:  Enzyme
Novelty:  0.00032205
Score:  0.655
Data Source:  STRINGDB
ANGEL1
Tbio
Novelty:  0.61303879
Score:  0.653
Data Source:  STRINGDB
KLHDC8B
Tbio
Novelty:  0.15409379
Score:  0.635
Data Source:  STRINGDB
RNF187
Tbio
Family:  Enzyme
Novelty:  0.13506464
Score:  0.623
Data Source:  STRINGDB
KBTBD12
Tdark
Novelty:  3.42794501
Score:  0.611
Data Source:  STRINGDB
KCNG3
Tclin
Family:  IC
Novelty:  0.19740057
Score:  0.59
Data Source:  STRINGDB
FIGNL1
Tbio
Family:  Enzyme
Novelty:  0.10817841
Score:  0.576
Data Source:  STRINGDB
TRAPPC6B
Tbio
Novelty:  0.15086531
Score:  0.571
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (21)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
9
12
97.9
blood protein measurement
2
3
3
82.8
brain measurement
1
1
0
20.4
77.1
cortical surface area measurement
1
1
0
13.3
72.9
cortical thickness
1
1
0
11.8
70.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
12
97.9
blood protein measurement
3
82.8
brain measurement
0
20.4
77.1
cortical surface area measurement
0
13.3
72.9
cortical thickness
0
11.8
70.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
protein kinase domain containing, cytoplasmic
VGNC:340
736991
Mouse
MGI:2147077
106522
Dog
protein kinase domain containing, cytoplasmic
VGNC:44603
611604
Horse
protein kinase domain containing, cytoplasmic
VGNC:51387
100069409
Cow
protein kinase domain containing, cytoplasmic
VGNC:32938
539467
Species
Name
OMA
EggNOG
Inparanoid
Chimp
protein kinase domain containing, cytoplasmic
Mouse
Dog
protein kinase domain containing, cytoplasmic
Horse
protein kinase domain containing, cytoplasmic
Cow
protein kinase domain containing, cytoplasmic
Publication Statistics
PubMed Score 28.56
PubMed score by year
PubTator Score 3.64
PubTator score by year
Patents
Patents by year
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Related Publications
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PMID
Year
Title