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Tbio
PKD2L2
Polycystic kidney disease 2-like 2 protein

Protein Summary
Description
May function as a subunit of a cation channel and play a role in fertilization.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000290431
  • ENSP00000290431
  • ENSG00000078795
  • ENST00000414094
  • ENSP00000388060
  • ENST00000502810
  • ENSP00000425513
  • ENST00000508638
  • ENSP00000423382
  • ENST00000508883
  • ENSP00000424725

Symbol
  • TRPP5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.82
molecular function
0.76
transcription factor binding site profile
0.59
cell type or tissue
0.56
gene perturbation
0.53


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.16   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 93   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.16   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 93   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (31)
PKD2
Tchem
Family:  IC
Novelty:  0.00305329
p_int:  0.999988736
p_ni:  0.000011264
Score:  0.221
Data Source:  BioPlex,STRINGDB
SERPINB4
Tbio
Novelty:  0.00522283
p_int:  0.965775527
p_ni:  0.034224473
Score:  0.378
Data Source:  BioPlex,STRINGDB
CCPG1
Tbio
Novelty:  0.07685013
p_int:  0.961104815
p_ni:  0.038895185
Score:  0.19
Data Source:  BioPlex,STRINGDB
SERPINB3
Tbio
Novelty:  0.00325244
p_int:  0.946710621
p_ni:  0.053289379
Score:  0.796
Data Source:  BioPlex,STRINGDB
PKD1L2
Tbio
Family:  IC
Novelty:  0.17684334
Score:  0.824
Data Source:  STRINGDB
CCBE1
Tbio
Novelty:  0.03290164
Score:  0.617
Data Source:  STRINGDB
MCOLN1
Tchem
Family:  IC
Novelty:  0.00442768
Score:  0.577
Data Source:  STRINGDB
TRPV4
Tchem
Family:  IC
Novelty:  0.00111193
Score:  0.546
Data Source:  STRINGDB
FZD5
Tbio
Family:  GPCR
Novelty:  0.01673829
Score:  0.54
Data Source:  STRINGDB
TRPC1
Tbio
Family:  IC
Novelty:  0.00233677
Score:  0.532
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
1
1
1
47.7
balding measurement
1
1
1
27.3
hematocrit
1
1
1
3.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
1
47.7
balding measurement
1
27.3
hematocrit
1
3.5
Find similar targets by:
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
polycystin 2 like 2, transient receptor potential cation channel
VGNC:7184
745945
Macaque
polycystin 2 like 2, transient receptor potential cation channel
713629
Mouse
MGI:1858231
53871
Rat
RGD:1310272
291683
Dog
polycystin 2 like 2, transient receptor potential cation channel
VGNC:44602
100855705
Species
Name
OMA
EggNOG
Inparanoid
Chimp
polycystin 2 like 2, transient receptor potential cation channel
Macaque
polycystin 2 like 2, transient receptor potential cation channel
Mouse
Rat
Dog
polycystin 2 like 2, transient receptor potential cation channel
Publication Statistics
PubMed Score 6.16
PubMed score by year
PubTator Score 2.84
PubTator score by year
Patents
Patents by year
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Related Publications
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PMID
Year
Title