Protein Summary
Component of a heteromeric calcium-permeable ion channel formed by PKD1 and PKD2 that is activated by interaction between PKD1 and a Wnt family member, such as WNT3A and WNT9B (PubMed:27214281). Can also form a functional, homotetrameric ion channel (PubMed:29899465). Functions as a cation channel involved in fluid-flow mechanosensation by the primary cilium in renal epithelium (PubMed:18695040). Functions as outward-rectifying K(+) channel, but is also permeable to Ca(2+), and to a much lesser degree also to Na(+) (PubMed:11854751, PubMed:15692563, PubMed:27071085, PubMed:27991905). May contribute to the release of Ca(2+) stores from the endoplasmic reticulum (PubMed:11854751, PubMed:20881056). Together with TRPV4, forms mechano- and thermosensitive channels in cilium (PubMed:18695040). PKD1 and PKD2 may function through a common signaling pathway that is necessary to maintain the normal, differentiated state of renal tubule cells. Acts as a regulator of cilium length, together with P ...more
- ENST00000237596
- ENSP00000237596
- ENSG00000118762
- TRPP2
- PC2
- PKD4
- Pc-2
- APKD2
- TRPP2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
biological process | 1 | ||
molecular function | 1 | ||
microRNA | 0.82 | ||
cell type or tissue | 0.81 | ||
kinase | 0.78 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 364.38 (req: < 5)
Gene RIFs: 156 (req: <= 3)
Antibodies: 302 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 364.38 (req: >= 5)
Gene RIFs: 156 (req: > 3)
Antibodies: 302 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 75
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 1
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (1)
Protein-Protein Interactions (141)
PKD2L2
Family: IC
Novelty: 0.12399184
p_int: 0.999988736
p_ni: 0.000011264
Score: 0.221
Data Source: BioPlex,STRINGDB
FAM3D
Novelty: 0.11834339
p_int: 0.999924722
p_ni: 0.000075278
Score: 0.455
Data Source: BioPlex,STRINGDB
ATP6V1D
Family: Enzyme
Novelty: 0.02298626
p_int: 0.99955135
p_ni: 0.000448644
p_wrong: 6e-9
Data Source: BioPlex
BCAS4
Novelty: 0.11759439
p_int: 0.999170247
p_ni: 0.000829753
Score: 0.187
Data Source: BioPlex,STRINGDB
CRYL1
Family: Enzyme
Novelty: 0.04513297
p_int: 0.998234404
p_ni: 0.001765596
Data Source: BioPlex
CHRND
Family: IC
Novelty: 0.0441685
p_int: 0.998047563
p_ni: 0.001952437
Score: 0.229
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (4)
Reactome (4)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Cargo trafficking to the periciliary membrane | ||||
Reactome | Cilium Assembly | ||||
Reactome | Organelle biogenesis and maintenance | ||||
Reactome | VxPx cargo-targeting to cilium | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Cargo trafficking to the periciliary membrane | ||||
Cilium Assembly | ||||
Organelle biogenesis and maintenance | ||||
VxPx cargo-targeting to cilium | ||||
Viral Interactions (0)
Gene Ontology Terms (97)
Functions (21)
Components (22)
Processes (54)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Disease Associations ()
GWAS Traits (30)
Items per page:
1 – 5 of 30
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
urate measurement | 13 | 16 | 26 | 6 | 99.9 | ||||
uric acid measurement | 13 | 8 | 18 | 1.9 | 99.4 | ||||
15 | 8 | 0 | 1.9 | 99.2 | |||||
coffee consumption measurement | 3 | 3 | 3 | 91.6 | |||||
tea consumption measurement | 2 | 2 | 2 | 89 | |||||
Items per page:
1 – 5 of 30
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
urate measurement | 26 | 6 | 99.9 | ||||
uric acid measurement | 18 | 1.9 | 99.4 | ||||
0 | 1.9 | 99.2 | |||||
coffee consumption measurement | 3 | 91.6 | |||||
tea consumption measurement | 2 | 89 | |||||
Find similar targets by:
IDG Resources
Orthologs (14)
1 – 5 of 14
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | polycystin 2, transient receptor potential cation channel | VGNC:7424 | 461367 | |||||
Macaque | polycystin 2, transient receptor potential cation channel | 702179 | ||||||
Mouse | MGI:1099818 | 18764 | ||||||
Rat | RGD:1559992 | 498328 | ||||||
Dog | polycystin 2, transient receptor potential cation channel | VGNC:44600 | 487852 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | polycystin 2, transient receptor potential cation channel | |||||
Macaque | polycystin 2, transient receptor potential cation channel | |||||
Mouse | ||||||
Rat | ||||||
Dog | polycystin 2, transient receptor potential cation channel | |||||
Publication Statistics
PubMed Score 364.38
PubMed score by year
PubTator Score 587.15
PubTator score by year
Patents
Patents by year
Related Publications
Text Mined References (196)
GeneRif Annotations (156)
Items per page:
0 of 0
PMID | Year | Title |
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