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Tbio
PKD1L2
Polycystic kidney disease protein 1-like 2

Protein Summary
Description
May function as an ion-channel regulator. May function as a G-protein-coupled receptor. This gene encodes a member of the polycystin protein family. The encoded protein contains 11 transmembrane domains, a latrophilin/CL-1-like GPCR proteolytic site (GPS) domain, and a polycystin-1, lipoxygenase, alpha-toxin (PLAT) domain. This protein may function as a component of cation channel pores. This gene appears to be a polymorphic pseudogene in humans, and the reference genome encodes a non-functional allele. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2019]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000337114
  • ENSP00000337397
  • ENSG00000166473
  • ENST00000527937
  • ENSP00000432818
  • ENST00000531391
  • ENSP00000436309

Symbol
  • KIAA1879
  • PC1L2
  • PC1L2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
microRNA
0.84
virus perturbation
0.68
tissue
0.63
trait
0.61


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.28   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 63   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.28   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 63   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (33)
PKD1L1
Tbio
Family:  IC
Novelty:  0.08309821
Score:  0.841
Data Source:  STRINGDB
PKD2L2
Tbio
Family:  IC
Novelty:  0.12399184
Score:  0.824
Data Source:  STRINGDB
PKD1L3
Tbio
Family:  IC
Novelty:  0.0517368
Score:  0.812
Data Source:  STRINGDB
PKD2L1
Tchem
Family:  IC
Novelty:  0.01605232
Score:  0.761
Data Source:  STRINGDB
PKD2
Tchem
Family:  IC
Novelty:  0.00305329
Score:  0.662
Data Source:  STRINGDB
PKD1
Tbio
Novelty:  0.00288432
Score:  0.653
Data Source:  STRINGDB
PRKD1
Tchem
Family:  Kinase
Novelty:  0.00128927
Score:  0.645
Data Source:  STRINGDB
PLAT
Tclin
Family:  Enzyme
Novelty:  0.00017503
Score:  0.64
Data Source:  STRINGDB
TMA16
Tdark
Novelty:  0.89810617
Score:  0.544
Data Source:  STRINGDB
GNA12
Tbio
Novelty:  0.06310884
Score:  0.542
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glycine measurement
6
5
7
13.5
99
mosaic loss of chromosome Y measurement
3
2
3
94.6
amino acid measurement
2
2
2
83.6
protein measurement
1
1
1
71.9
blood metabolite measurement
1
1
1
71.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glycine measurement
7
13.5
99
mosaic loss of chromosome Y measurement
3
94.6
amino acid measurement
2
83.6
protein measurement
1
71.9
blood metabolite measurement
1
71.9
Find similar targets by:
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
polycystin 1 like 2
717465
Mouse
MGI:2664668
76645
Dog
polycystin 1 like 2
489696
Anole lizard
polycystin 1 like 2
100566237
Species
Name
OMA
EggNOG
Inparanoid
Macaque
polycystin 1 like 2
Mouse
Dog
polycystin 1 like 2
Anole lizard
polycystin 1 like 2
Publication Statistics
PubMed Score 5.28
PubMed score by year
PubTator Score 4.14
PubTator score by year
Patents
Patents by year
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Related Publications
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PMID
Year
Title