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Tbio
PKD1L1
Polycystic kidney disease protein 1-like 1

Protein Summary
Description
Component of a ciliary calcium channel that controls calcium concentration within primary cilia without affecting cytoplasmic calcium concentration. Forms a heterodimer with PKD2L1 in primary cilia and forms a calcium-permeant ciliary channel that regulates sonic hedgehog/SHH signaling and GLI2 transcription. Does not constitute the pore-forming subunit. Also involved in left/right axis specification downstream of nodal flow: forms a complex with PKD2 in cilia to facilitate flow detection in left/right patterning. This gene encodes a member of the polycystin protein family containing 11 transmembrane domains, a receptor for egg jelly (REJ) domain, and a polycystin-1, lipoxygenase, alpha-toxin (PLAT) domain. The encoded protein may play a role in the male reproductive system. Alternative splice variants have been described but their biological nature has not been determined. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000289672
  • ENSP00000289672
  • ENSG00000158683

Symbol
  • HTX8
  • PRO19563
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
molecular function
0.67
tissue
0.67
tissue sample
0.6
cell type or tissue
0.56


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.56   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 54   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.56   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 54   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (27)
PKD1L2
Tbio
Family:  IC
Novelty:  0.17684334
Score:  0.841
Data Source:  STRINGDB
GLIS3
Tbio
Family:  TF
Novelty:  0.0018696
Score:  0.667
Data Source:  STRINGDB
ZIC1
Tbio
Family:  TF
Novelty:  0.00491601
Score:  0.644
Data Source:  STRINGDB
SCNN1D
Tbio
Family:  IC
Novelty:  0.06191685
Score:  0.639
Data Source:  STRINGDB
GNA12
Tbio
Novelty:  0.06310884
Score:  0.626
Data Source:  STRINGDB
UNG
Tbio
Family:  Enzyme
Novelty:  0.00268354
Score:  0.625
Data Source:  STRINGDB
SCNN1B
Tclin
Family:  IC
Novelty:  0.01281284
Score:  0.592
Data Source:  STRINGDB
PRKD1
Tchem
Family:  Kinase
Novelty:  0.00128927
Score:  0.565
Data Source:  STRINGDB
GNAI2
Tchem
Novelty:  0.03014729
Score:  0.55
Data Source:  STRINGDB
PLAT
Tclin
Family:  Enzyme
Novelty:  0.00017503
Score:  0.533
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
corneal topography
3
1
3
45.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
corneal topography
3
45.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
polycystin 1 like 1, transient receptor potential channel interacting
VGNC:4469
463401
Mouse
MGI:2156538
171395
Rat
RGD:1564724
289796
Dog
polycystin 1 like 1, transient receptor potential channel interacting
VGNC:44598
491575
Horse
polycystin 1 like 1, transient receptor potential channel interacting
VGNC:21488
100066061
Species
Name
OMA
EggNOG
Inparanoid
Chimp
polycystin 1 like 1, transient receptor potential channel interacting
Mouse
Rat
Dog
polycystin 1 like 1, transient receptor potential channel interacting
Horse
polycystin 1 like 1, transient receptor potential channel interacting
Publication Statistics
PubMed Score 12.56
PubMed score by year
PubTator Score 2.79
PubTator score by year
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Related Publications
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PMID
Year
Title