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Tbio
PJVK
Pejvakin

Protein Summary
Description
Essential in the activity of auditory pathway neurons. The protein encoded by this gene is a member of the gasdermin family, a family which is found only in vertebrates. The encoded protein is required for the proper function of auditory pathway neurons. Defects in this gene are a cause of non-syndromic sensorineural deafness autosomal recessive type 59 (DFNB59). [provided by RefSeq, Dec 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000375129
  • ENSP00000364271
  • ENSG00000204311
  • ENST00000409117
  • ENSP00000386647
  • ENST00000644580
  • ENSP00000495855

Symbol
  • DFNB59
  • DFNB59
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.58   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 59   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.58   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 59   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (51)
DIAPH3
Tbio
Novelty:  0.01165283
Score:  0.826
Data Source:  STRINGDB
OTOF
Tbio
Novelty:  0.00676341
Score:  0.791
Data Source:  STRINGDB
GIPC3
Tbio
Novelty:  0.14970604
Score:  0.788
Data Source:  STRINGDB
TMC1
Tbio
Family:  IC
Novelty:  0.00609628
Score:  0.739
Data Source:  STRINGDB
BSND
Tbio
Novelty:  0.01638636
Score:  0.719
Data Source:  STRINGDB
TMEM126A
Tbio
Novelty:  0.11759225
Score:  0.709
Data Source:  STRINGDB
OSBPL3
Tbio
Novelty:  0.06106368
Score:  0.692
Data Source:  STRINGDB
TMPRSS3
Tbio
Family:  Enzyme
Novelty:  0.0268524
Score:  0.679
Data Source:  STRINGDB
OTOA
Tbio
Novelty:  0.04940755
Score:  0.678
Data Source:  STRINGDB
SLC26A4
Tbio
Family:  Transporter
Novelty:  0.00162006
Score:  0.675
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (2)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations (null)
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
2
0
1.1
88.2
electrocardiography
1
2
5
82
aspartate aminotransferase measurement
1
1
0
8.1
65.6
heart function measurement
2
1
2
60.2
left ventricular diastolic function measurement
1
1
0
2
50.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
88.2
electrocardiography
5
82
aspartate aminotransferase measurement
0
8.1
65.6
heart function measurement
2
60.2
left ventricular diastolic function measurement
0
2
50.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
pejvakin
VGNC:163
459777
Mouse
MGI:2685847
381375
Dog
pejvakin
VGNC:44596
478817
Horse
pejvakin
VGNC:21486
100053789
Cow
pejvakin
VGNC:32932
618114
Species
Name
OMA
EggNOG
Inparanoid
Chimp
pejvakin
Mouse
Dog
pejvakin
Horse
pejvakin
Cow
pejvakin
Publication Statistics
PubMed Score 25.58
PubMed score by year
PubTator Score 15.90
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title