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Tbio
PITX2
Pituitary homeobox 2

Protein Summary
Description
Controls cell proliferation in a tissue-specific manner and is involved in morphogenesis. During embryonic development, exerts a role in the expansion of muscle progenitors. May play a role in the proper localization of asymmetric organs such as the heart and stomach. Isoform PTX2C is involved in left-right asymmetry the developing embryo (By similarity). This gene encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. The encoded protein acts as a transcription factor and regulates procollagen lysyl hydroxylase gene expression. This protein plays a role in the terminal differentiation of somatotroph and lactotroph cell phenotypes, is involved in the development of the eye, tooth and abdominal organs, and acts as a transcriptional regulator involved in basal and hormone-regulated activity of prolactin. Mutations in this gene are associated with Axenfeld-Rieger syndrome, iridogoniodysgenesis syndrome, and sporadic cases of Peters anomaly ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000306732
  • ENSP00000304169
  • ENSG00000164093
  • ENST00000354925
  • ENSP00000347004
  • ENST00000355080
  • ENSP00000347192
  • ENST00000394595
  • ENSP00000378095
  • ENST00000394598
  • ENSP00000378097
  • ENST00000613094
  • ENSP00000484763
  • ENST00000614423
  • ENSP00000481951
  • ENST00000616641
  • ENSP00000484909
  • ENST00000644743
  • ENSP00000495061

Symbol
  • ARP1
  • RGS
  • RIEG
  • RIEG1
  • RS
  • RGS
  • ARP1
  • Brx1
  • IDG2
  • IGDS
  • IHG2
  • PTX2
  • RIEG
  • ASGD4
  • IGDS2
  • IRID2
  • Otlx2
  • RIEG1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.99
molecular function
0.99
hub protein
0.98
PubMedID
0.88
transcription factor
0.83


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 603.41   (req: < 5)
Gene RIFs: 135   (req: <= 3)
Antibodies: 269   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 603.41   (req: >= 5)
Gene RIFs: 135   (req: > 3)
Antibodies: 269   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 31
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0