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Tchem
PITRM1
Presequence protease, mitochondrial

Protein Summary
Description
Metalloendopeptidase of the mitochondrial matrix that functions in peptide cleavage and degradation rather than in protein processing (PubMed:10360838, PubMed:16849325, PubMed:19196155, PubMed:24931469). Has an ATP-independent activity (PubMed:16849325). Specifically cleaves peptides in the range of 5 to 65 residues (PubMed:19196155). Shows a preference for cleavage after small polar residues and before basic residues, but without any positional preference (PubMed:10360838, PubMed:19196155, PubMed:24931469). Degrades the transit peptides of mitochondrial proteins after their cleavage (PubMed:19196155). Also degrades other unstructured peptides (PubMed:19196155). It is also able to degrade amyloid-beta protein 40, one of the peptides produced by APP processing, when it accumulates in mitochondrion (PubMed:16849325, PubMed:24931469). It is a highly efficient protease, at least toward amyloid-beta protein 40 (PubMed:24931469). Cleaves that peptide at a specific position and is probably no ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000224949
  • ENSP00000224949
  • ENSG00000107959
  • ENST00000380989
  • ENSP00000370377
  • ENST00000451104
  • ENSP00000401201

Symbol
  • KIAA1104
  • MP1
  • MP1
  • PreP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.88
histone modification site profile
0.81
transcription factor binding site profile
0.74
protein domain
0.73
tissue sample
0.72


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 167   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 167   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (110)
NID2
Tbio
Novelty:  0.01638372
p_int:  0.998834776
p_ni:  0.001164957
p_wrong:  2.67e-7
Data Source:  BioPlex
AGO4
Tbio
Novelty:  0.00468833
p_int:  0.992539276
p_ni:  0.000001017
p_wrong:  0.007459708
Data Source:  BioPlex
SNX17
Tbio
Novelty:  0.03960737
p_int:  0.989544059
p_ni:  0.010455941
Data Source:  BioPlex
CCL22
Tbio
Novelty:  0.00245992
p_int:  0.95811078
p_ni:  0.04188922
Score:  0.179
Data Source:  BioPlex,STRINGDB
DEFB104A
Tbio
Novelty:  0.0468791
p_int:  0.945686757
p_ni:  0.054313243
Data Source:  BioPlex
RARS2
Tbio
Family:  Enzyme
Novelty:  0.01185296
p_int:  0.937274512
p_ni:  0.062725488
Score:  0.326
Data Source:  BioPlex,STRINGDB
LNP1
Tdark
Novelty:  0.00457285
p_int:  0.903114079
p_ni:  0.096885921
Data Source:  BioPlex
DCTN3
Tbio
Novelty:  0.14551388
p_int:  0.88269531
p_ni:  0.11730469
Data Source:  BioPlex
CGB2
Tdark
Novelty:  0.00598131
p_int:  0.875498154
p_ni:  0.124501846
Data Source:  BioPlex
TEKT3
Tbio
Novelty:  0.06646482
p_int:  0.867494196
p_ni:  0.132505804
Score:  0.199
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (2)
Mitochondrial protein import (R-HSA-1268020)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Mitochondrial protein import
Reactome
Protein localization
Name
Explore in Pharos
Explore in Source
Mitochondrial protein import
Protein localization
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
2
3
75.6
hematocrit
2
2
2
45.1
airway imaging measurement
1
1
1
40.7
HbA1c measurement
1
1
1
31.4
hemoglobin measurement
1
1
1
2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
75.6
hematocrit
2
45.1
airway imaging measurement
1
40.7
HbA1c measurement
1
31.4
hemoglobin measurement
1
2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
pitrilysin metallopeptidase 1
VGNC:7251
450267
Macaque
pitrilysin metallopeptidase 1
710684
Mouse
MGI:1916867
69617
Rat
RGD:1310998
307081
Dog
pitrilysin metallopeptidase 1
VGNC:44588
478018
Species
Name
OMA
EggNOG
Inparanoid
Chimp
pitrilysin metallopeptidase 1
Macaque
pitrilysin metallopeptidase 1
Mouse
Rat
Dog
pitrilysin metallopeptidase 1
Publication Statistics
PubMed Score 19.00
PubMed score by year
PubTator Score 203.72
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title