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Tbio
PITPNM1
Membrane-associated phosphatidylinositol transfer protein 1

Protein Summary
Description
Regulates RHOA activity, and plays a role in cytoskeleton remodeling. Necessary for normal completion of cytokinesis. Plays a role in maintaining normal diacylglycerol levels in the Golgi apparatus. Binds phosphatidyl inositol phosphates (in vitro). May catalyze the transfer of phosphatidylinositol and phosphatidylcholine between membranes (By similarity). Necessary for maintaining the normal structure of the endoplasmic reticulum and the Golgi apparatus. Required for protein export from the endoplasmic reticulum and the Golgi. Binds calcium ions. PITPNM1 belongs to a family of membrane-associated phosphatidylinositol transfer domain-containing proteins that share homology with the Drosophila retinal degeneration B (rdgB) protein (Ocaka et al., 2005 [PubMed 15627748]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000356404
  • ENSP00000348772
  • ENSG00000110697
  • ENST00000436757
  • ENSP00000398787
  • ENST00000534749
  • ENSP00000437286

Symbol
  • DRES9
  • NIR2
  • PITPNM
  • Rd9
  • NIR2
  • RDGB
  • DRES9
  • RDGB1
  • RDGBA
  • PITPNM
  • RDGBA1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
metabolite
0.98
disease perturbation
0.95
cellular component
0.81
transcription factor perturbation
0.8
protein domain
0.73


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 172.69   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 209   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 172.69   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 209   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (70)
VAPA
Tbio
Novelty:  0.00169209
p_int:  0.999999984
p_ni:  1.2e-8
p_wrong:  4e-9
Score:  0.842
Data Source:  BioPlex,STRINGDB
VAPB
Tbio
Novelty:  0.00542377
p_int:  0.999999949
p_ni:  2e-9
p_wrong:  4.9e-8
Score:  0.832
Data Source:  BioPlex,STRINGDB
PTK2B
Tclin
Family:  Kinase
Novelty:  0.00174314
Score:  0.95
Data Source:  STRINGDB
PDE6B
Tclin
Family:  Enzyme
Novelty:  0.001105
Score:  0.787
Data Source:  STRINGDB
OCM2
Tdark
Novelty:  0.08257025
Score:  0.775
Data Source:  STRINGDB
OCM
Tbio
Novelty:  0.00702069
Score:  0.772
Data Source:  STRINGDB
PTPRQ
Tbio
Family:  Enzyme
Novelty:  0.06874197
Score:  0.76
Data Source:  STRINGDB
PTPRR
Tbio
Family:  Enzyme
Novelty:  0.02065754
Score:  0.749
Data Source:  STRINGDB
OSBP
Tbio
Novelty:  0.00425747
Score:  0.698
Data Source:  STRINGDB
CDK1
Tchem
Family:  Kinase
Novelty:  0.00040776
Score:  0.689
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Glycerophospholipid biosynthesis (R-HSA-1483206)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Glycerophospholipid biosynthesis
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Phospholipid metabolism
Reactome
Synthesis of PI
Name
Explore in Pharos
Explore in Source
Glycerophospholipid biosynthesis
Metabolism
Metabolism of lipids
Phospholipid metabolism
Synthesis of PI
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (24)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations (null)
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
1
3
3
94.9
body height
2
2
2
94.5
mean corpuscular hemoglobin concentration
2
2
2
89
mean corpuscular volume
2
2
2
86.7
BMI-adjusted hip circumference
2
2
2
68.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
3
94.9
body height
2
94.5
mean corpuscular hemoglobin concentration
2
89
mean corpuscular volume
2
86.7
BMI-adjusted hip circumference
2
68.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
phosphatidylinositol transfer protein membrane associated 1
VGNC:3068
100607998
Macaque
phosphatidylinositol transfer protein membrane associated 1
721716
Mouse
MGI:1197524
18739
Rat
RGD:1306710
361694
Dog
phosphatidylinositol transfer protein membrane associated 1
VGNC:44586
610462
Species
Name
OMA
EggNOG
Inparanoid
Chimp
phosphatidylinositol transfer protein membrane associated 1
Macaque
phosphatidylinositol transfer protein membrane associated 1
Mouse
Rat
Dog
phosphatidylinositol transfer protein membrane associated 1
Publication Statistics
PubMed Score 172.69
PubMed score by year
PubTator Score 31.09
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title