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Tbio
PITPNA
Phosphatidylinositol transfer protein alpha isoform

Protein Summary
Description
Catalyzes the transfer of PtdIns and phosphatidylcholine between membranes. This gene encodes a member of a family of lipid-binding proteins that transfer molecules of phosphatidylinositol or phosphatidylcholine between membrane surfaces. The protein is implicated in phospholipase C signaling and in the production of phosphatidylinositol 3,4,5-trisphosphate (PIP3) by phosphoinositide-3-kinase.[provided by RefSeq, Sep 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000313486
  • ENSP00000316809
  • ENSG00000174238

Symbol
  • PITPN
  • PITPN
  • VIB1A
  • HEL-S-36
  • PI-TPalpha
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
kinase perturbation
0.95
interacting protein
0.87
metabolite
0.86
transcription factor perturbation
0.8


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 62.1   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 170   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 62.1   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 170   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (56)
S1PR4
Tclin
Family:  GPCR
Novelty:  0.01523676
p_int:  0.77908597
p_ni:  0.22091403
Score:  0.692
Data Source:  BioPlex,STRINGDB
PLCG1
Tchem
Family:  Enzyme
Novelty:  0.00110273
Score:  0.945
Data Source:  STRINGDB
DCC
Tbio
Novelty:  0.01273911
Score:  0.941
Data Source:  Reactome,STRINGDB
NTN1
Tbio
Novelty:  0.00183678
Score:  0.912
Data Source:  Reactome,STRINGDB
STAT4
Tchem
Family:  TF
Novelty:  0.00251747
Score:  0.902
Data Source:  STRINGDB
ACP1
Tchem
Family:  Enzyme
Novelty:  0.00409713
Score:  0.823
Data Source:  STRINGDB
SCARF1
Tbio
Novelty:  0.00938046
Score:  0.804
Data Source:  STRINGDB
YWHAE
Tbio
Novelty:  0.00431876
Score:  0.762
Data Source:  STRINGDB
MYO1E
Tbio
Novelty:  0.01506519
Score:  0.749
Data Source:  STRINGDB
MYO1C
Tbio
Novelty:  0.00967011
Score:  0.749
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (12)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Cytokine Signaling in Immune system
Reactome
Developmental Biology
Reactome
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Axon guidance
Cytokine Signaling in Immune system
Developmental Biology
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
Immune System
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (14)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Traceable Author Statement (TAS)
BHF-UCL
Disease Associations (null)
No disease associations found
GWAS Traits (21)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
4
4
94.1
reticulocyte measurement
1
3
3
89.8
reticulocyte count
2
3
4
89.7
lymphocyte percentage of leukocytes
2
3
3
89.6
neutrophil count
3
2
3
80.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
4
94.1
reticulocyte measurement
3
89.8
reticulocyte count
4
89.7
lymphocyte percentage of leukocytes
3
89.6
neutrophil count
3
80.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
phosphatidylinositol transfer protein alpha
VGNC:9526
747193
Mouse
MGI:99887
18738
Rat
RGD:61885
29525
Dog
phosphatidylinositol transfer protein alpha
VGNC:44583
480648
Horse
phosphatidylinositol transfer protein alpha
VGNC:21473
100060018
Species
Name
OMA
EggNOG
Inparanoid
Chimp
phosphatidylinositol transfer protein alpha
Mouse
Rat
Dog
phosphatidylinositol transfer protein alpha
Horse
phosphatidylinositol transfer protein alpha
Publication Statistics
PubMed Score 62.10
PubMed score by year
PubTator Score 23.89
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title