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Tdark
PITHD1
PITH domain-containing protein 1

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000246151
  • ENSP00000246151
  • ENSG00000057757

Symbol
  • C1orf128
  • HT014
  • TXNL1CL
  • C1orf128
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.91
kinase perturbation
0.81
transcription factor perturbation
0.8
transcription factor binding site profile
0.68
disease perturbation
0.62


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.43   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 10   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.43   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 10   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (31)
WDR59
Tdark
Novelty:  0.22243351
p_int:  0.999619518
p_ni:  0.000380482
Score:  0.212
Data Source:  BioPlex,STRINGDB
METTL9
Tdark
Family:  Enzyme
Novelty:  0.20589257
p_int:  0.99263836
p_ni:  0.007360659
p_wrong:  9.81e-7
Data Source:  BioPlex
CRMP1
Tbio
Family:  Enzyme
Novelty:  0.01998451
p_int:  0.988691706
p_ni:  0.011308294
Score:  0.187
Data Source:  BioPlex,STRINGDB
EEF1A2
Tchem
Novelty:  0.001472
p_int:  0.975137665
p_ni:  0.024862335
Score:  0.161
Data Source:  BioPlex,STRINGDB
ANKRD39
Tdark
Novelty:  8.68843298
p_int:  0.931101669
p_ni:  0.067169276
p_wrong:  0.001729055
Data Source:  BioPlex
FNTB
Tclin
Family:  Enzyme
Novelty:  0.07434994
p_int:  0.892490525
p_ni:  0.107509475
Data Source:  BioPlex
TAX1BP3
Tbio
Novelty:  0.01605171
p_int:  0.868495685
p_ni:  0.131502949
p_wrong:  0.000001367
Data Source:  BioPlex
RPRD1A
Tbio
Novelty:  0.13521196
p_int:  0.813331607
p_ni:  0.186638857
p_wrong:  0.000029536
Score:  0.189
Data Source:  BioPlex,STRINGDB
RECQL5
Tbio
Family:  Enzyme
Novelty:  0.01558497
p_int:  0.767124239
p_ni:  0.177207493
p_wrong:  0.055668267
Score:  0.228
Data Source:  BioPlex,STRINGDB
YWHAB
Tchem
Novelty:  0.00614093
Score:  0.864
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (1)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
6
4
6
92.4
eosinophil count
3
3
3
91.9
reticulocyte measurement
3
2
3
90.5
eosinophil percentage of leukocytes
2
2
2
85.5
eosinophil percentage of granulocytes
1
1
1
35
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
6
92.4
eosinophil count
3
91.9
reticulocyte measurement
3
90.5
eosinophil percentage of leukocytes
2
85.5
eosinophil percentage of granulocytes
1
35
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
PITH domain containing 1
VGNC:10031
456621
Macaque
PITH domain containing 1
710737
Mouse
MGI:1913443
66193
Rat
RGD:1308048
298557
Dog
PITH domain containing 1
VGNC:44582
612304
Species
Name
OMA
EggNOG
Inparanoid
Chimp
PITH domain containing 1
Macaque
PITH domain containing 1
Mouse
Rat
Dog
PITH domain containing 1
Publication Statistics
PubMed Score 4.43
PubMed score by year
PubTator Score 1.00
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title