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Tbio
PIP5KL1
Phosphatidylinositol 4-phosphate 5-kinase-like protein 1

Protein Summary
Description
May act as a scaffold to localize and regulate type I PI(4)P 5-kinases to specific compartments within the cell, where they generate PI(4,5)P2 for actin nucleation, signaling and scaffold protein recruitment and conversion to PI(3,4,5)P3. PIP5KL1 is a phosphoinositide kinase-like protein that lacks intrinsic lipid kinase activity but associates with type I PIPKs (see PIP5K1A; MIM 603275) and may play a role in localization of PIPK activity (Chang et al., 2004 [PubMed 14701839]).[supplied by OMIM, Jun 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000300432
  • ENSP00000300432
  • ENSG00000167103
  • ENST00000388747
  • ENSP00000373399

Symbol
  • PIPKH
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.9
tissue sample
0.66
transcription factor
0.64
histone modification site profile
0.61
protein domain
0.58


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.15   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 136   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.15   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 136   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (64)
PIK3CD
Tclin
Family:  Kinase
Novelty:  0.00572779
Score:  0.97
Data Source:  STRINGDB
PIK3CB
Tchem
Family:  Kinase
Novelty:  0.00390277
Score:  0.955
Data Source:  STRINGDB
PLCH2
Tbio
Family:  Enzyme
Novelty:  0.06394965
Score:  0.953
Data Source:  STRINGDB
PLCD4
Tbio
Family:  Enzyme
Novelty:  0.07014141
Score:  0.948
Data Source:  STRINGDB
PLCZ1
Tbio
Family:  Enzyme
Novelty:  0.0059826
Score:  0.947
Data Source:  STRINGDB
PLCH1
Tbio
Family:  Enzyme
Novelty:  0.11128204
Score:  0.947
Data Source:  STRINGDB
PLCD3
Tbio
Family:  Enzyme
Novelty:  0.04749421
Score:  0.943
Data Source:  STRINGDB
PI4KB
Tchem
Family:  Kinase
Novelty:  0.00856875
Score:  0.942
Data Source:  STRINGDB
PLCD1
Tchem
Family:  Enzyme
Novelty:  0.00742197
Score:  0.94
Data Source:  STRINGDB
PI4KA
Tchem
Family:  Kinase
Novelty:  0.01701469
Score:  0.94
Data Source:  STRINGDB
Pathways (10)
Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
Inositol phosphate metabolism
KEGG
Endocytosis
KEGG
Metabolic pathways
Name
Explore in Pharos
Explore in Source
Inositol phosphate metabolism
Endocytosis
Metabolic pathways
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hemoglobin measurement
3
3
3
93.9
hematocrit
3
2
3
86.8
monocyte count
3
3
3
82.1
urate measurement
3
3
3
76.4
red blood cell density measurement
1
1
1
43.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hemoglobin measurement
3
93.9
hematocrit
3
86.8
monocyte count
3
82.1
urate measurement
3
76.4
red blood cell density measurement
1
43.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
phosphatidylinositol-4-phosphate 5-kinase like 1
VGNC:9186
464758
Mouse
MGI:2448520
227733
Dog
phosphatidylinositol-4-phosphate 5-kinase like 1
VGNC:44577
609122
Horse
phosphatidylinositol-4-phosphate 5-kinase like 1
VGNC:21468
100070364
Cow
phosphatidylinositol-4-phosphate 5-kinase like 1
VGNC:32913
523736
Species
Name
OMA
EggNOG
Inparanoid
Chimp
phosphatidylinositol-4-phosphate 5-kinase like 1
Mouse
Dog
phosphatidylinositol-4-phosphate 5-kinase like 1
Horse
phosphatidylinositol-4-phosphate 5-kinase like 1
Cow
phosphatidylinositol-4-phosphate 5-kinase like 1
Publication Statistics
PubMed Score 7.15
PubMed score by year
PubTator Score 2.67
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title