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Tbio
PIP5K1B
Phosphatidylinositol 4-phosphate 5-kinase type-1 beta

Protein Summary
Description
Participates in the biosynthesis of phosphatidylinositol 4,5-bisphosphate. Mediates RAC1-dependent reorganization of actin filaments. Contributes to the activation of PLD2. Together with PIP5K1A is required after stimulation of G-protein coupled receptors for stable platelet adhesion (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265382
  • ENSP00000265382
  • ENSG00000107242
  • ENST00000478500
  • ENSP00000435778
  • ENST00000541509
  • ENSP00000438082

Symbol
  • STM7
  • MSS4
  • STM7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.91
drug perturbation
0.87
transcription factor perturbation
0.84
histone modification site profile
0.79
transcription factor binding site profile
0.78


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.91   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 137   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.91   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 137   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0