Tchem PIP4K2C Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma

Protein Summary

Description

May play an important role in the production of Phosphatidylinositol bisphosphate (PIP2), in the endoplasmic reticulum.

Uniprot Accession IDs

• Q8TBX8
• B2RDL3
• B4DM11
• B4DY44
• Q9H6N2

Gene Name

• PIP4K2C

Ensembl ID

• ENST00000354947
• ENSP00000347032
• ENSG00000166908
• ENST00000422156
• ENSP00000412035
• ENST00000540759
• ENSP00000439878
• ENST00000550465
• ENSP00000447390

Symbol

• PIP5K2C
• PIP5K2C

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.95
molecular function	0.93
kinase perturbation	0.88
histone modification site profile	0.74
interacting protein	0.74

Protein Classes

PANTHER Classes

Protein / Transferase / Kinase / Phosphatidylinositol 5-phosphate 4-kinase Type-2 Gamma

DTO Classes

Protein / Kinase / Non-protein Kinase / Lipid Kinase / Phosphatidylinositol 5-phosphate 4-kinase Type-2 Gamma

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.31   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 99   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.31   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 99   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 6

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

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ProtVista Viewer

Related Tools (6)

Dark Kinase Knowledgebase

The Dark Kinase Knowledgebase is an an online compendium of knowledge and experimental results of understudied kinases.

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ProKinO

The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.

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Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (6)

Explore Active Ligands

1 – 6 of 6

foretinib

PIP4K2CTchem Kinase

pKd : 7.92

OTS-167

PIP4K2CTchem Kinase

pKd : 7.55

CHEMBL4454033

PIP4K2CTchem Kinase

pKd : 10.64

CHEMBL4436648

PIP4K2CTchem Kinase

pKd : 8.8

CHEMBL4455633

PIP4K2CTchem Kinase

pKd : 8.47

CHEMBL4446338

PIP4K2CTchem Kinase

pKd : 8.32

Protein-Protein Interactions (123)

Explore Interacting Targets

1 – 10 of 123

• See Interactions on String-DB

PIP4K2A

Tbio

Family:  Kinase

Novelty:  0.01130885

p_int:  0.999999665

p_ni:  3.35e-7

p_wrong:  1e-9

Score:  0.934

Data Source:  BioPlex,Reactome,STRINGDB

HDGFL2

Tbio

Family:  Epigenetic

Novelty:  0.11846257

p_int:  0.999998557

p_ni:  0.000001443

Data Source:  BioPlex

ATG4C

Tbio

Family:  Enzyme

Novelty:  0.04175533

p_int:  0.999986898

p_ni:  0.000013102

Data Source:  BioPlex

ARHGAP22

Tbio

Family:  Enzyme

Novelty:  0.13037853

p_int:  0.999903998

p_ni:  0.000095994

p_wrong:  8e-9

Data Source:  BioPlex

AHCYL2

Tbio

Family:  Enzyme

Novelty:  0.08695339

p_int:  0.999882431

p_ni:  0.000117569

Data Source:  BioPlex

LZTS2

Tbio

Novelty:  0.09515452

p_int:  0.99982937

p_ni:  0.00017063

p_wrong:  1e-9

Score:  0.207

Data Source:  BioPlex,STRINGDB

EAF1

Tbio

Novelty:  0.81120425

p_int:  0.999734278

p_ni:  0.000265722

Data Source:  BioPlex

GPBP1L1

Tdark

Novelty:  0.69320833

p_int:  0.999711694

p_ni:  0.000288306

Data Source:  BioPlex

AHCYL1

Tchem

Family:  Enzyme

Novelty:  0.02176432

p_int:  0.999702832

p_ni:  0.000297161

p_wrong:  8e-9

Data Source:  BioPlex

PRICKLE3

Tbio

Novelty:  0.26347141

p_int:  0.999678241

p_ni:  0.000321759

Data Source:  BioPlex

Nearest Tclin Targets (6)

Explore Nearest Tclin Targets

Upstream (4)

Downstream (2)

1 – 4 of 4

PIK3CD

Tclin

Family:  Kinase

KEGG Distance:  1

Common Pathways:  4

1: Inositol phosphate metabolism

2: Regulation of actin cytoskeleton

3: Metabolic pathways

4: Phosphatidylinositol signaling system

PIK3CA

Tclin

Family:  Kinase

KEGG Distance:  1

Common Pathways:  4

1: Inositol phosphate metabolism

2: Regulation of actin cytoskeleton

3: Metabolic pathways

4: Phosphatidylinositol signaling system

ROCK2

Tclin

Family:  Kinase

KEGG Distance:  1

Common Pathways:  1

1: Regulation of actin cytoskeleton

ROCK1

Tclin

Family:  Kinase

KEGG Distance:  1

Common Pathways:  1

1: Regulation of actin cytoskeleton

Pathways (134)

Reactome (18)

KEGG (4)

PathwayCommons (5)

WikiPathways (107)

Gene expression (Transcription) (R-HSA-74160)

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5

1 – 5 of 18

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Gene expression (Transcription)	1452 targets	R-HSA-74160
Reactome	Generic Transcription Pathway	1195 targets	R-HSA-212436
Reactome	Intracellular signaling by second messengers	305 targets	R-HSA-9006925
Reactome	Metabolism	2112 targets	R-HSA-1430728
Reactome	Metabolism of lipids	740 targets	R-HSA-556833

Name	Explore in Pharos	Explore in Source
Gene expression (Transcription)	1452 targets	R-HSA-74160
Generic Transcription Pathway	1195 targets	R-HSA-212436
Intracellular signaling by second messengers	305 targets	R-HSA-9006925
Metabolism	2112 targets	R-HSA-1430728
Metabolism of lipids	740 targets	R-HSA-556833

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (11)

Functions (3)

Components (4)

Processes (4)

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Items per page:

10

1 – 3 of 3

GO Term	Evidence	Assigned by
1-phosphatidylinositol-5-phosphate 4-kinase activity	Inferred from Experiment (EXP)	Reactome
identical protein binding	Inferred from Physical Interaction (IPI)	IntAct
ATP binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Disease Associations (null)

No disease associations found

GWAS Traits (8)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 8

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
urate measurement	EFO_0004531	1	2	2		80.9
amyotrophic lateral sclerosis	EFO_0000253	1	1	0	1.4	56.4
body fat distribution	EFO_0004341	1	1	2		31.4
IGF-1 measurement	EFO_0004627	1	1	1		30.2
systolic blood pressure	EFO_0006335	1	1	1		29.9

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 8

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
urate measurement	EFO_0004531	2		80.9
amyotrophic lateral sclerosis	EFO_0000253	0	1.4	56.4
body fat distribution	EFO_0004341	2		31.4
IGF-1 measurement	EFO_0004627	1		30.2
systolic blood pressure	EFO_0006335	1		29.9

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Acetylation
Alternative splicing
ATP-binding
Complete proteome
Cytoplasm
Kinase
Membrane
Nucleotide-binding
Phosphoprotein

GWAS Trait Find Similar Targets

No Header	No Header
amyotrophic lateral sclerosis
apolipoprotein A 1 measurement
body fat distribution
high density lipoprotein cholesterol measurement
IGF-1 measurement
systolic blood pressure
type II diabetes mellitus
urate measurement

MGI Phenotype Find Similar Targets

No Header	No Header
cellular phenotype
digestive/alimentary phenotype
endocrine/exocrine gland phenotype
growth/size/body region phenotype
hematopoietic system phenotype
homeostasis/metabolism phenotype
immune system phenotype
liver/biliary system phenotype
renal/urinary system phenotype
respiratory system phenotype

IDG Resources

Reagents (1)

Data Resources (1)

Chemical Tool

1-((1H-imidazol-2-yl)methyl)-3-(1-(2-chlorophenyl)-3-(pyridin-3-yl)-4,5-dihydro-1H-thiazolo[4,5-g]indazol-7-yl)urea

Details:

• ChEBI:  156469
• Provider:  UNC-CH
• Activity:  NA
• Selectivity:  NA

Data:

• BI00048423

Order Chemical Tool from:

https://www.sgc-unc.org/request-idg-tools

Orthologs (10)

1 – 5 of 10

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	phosphatidylinositol-5-phosphate 4-kinase type 2 gamma	VGNC:13339	467044
Mouse	phosphatidylinositol-5-phosphate 4-kinase, type II, gamma	MGI:2152214	117150
Rat	phosphatidylinositol-5-phosphate 4-kinase type 2 gamma	RGD:621711	140607
Dog	phosphatidylinositol-5-phosphate 4-kinase type 2 gamma	VGNC:44572	474417
Horse	phosphatidylinositol-5-phosphate 4-kinase type 2 gamma	VGNC:21464	100053518

Species	Name	OMA	EggNOG	Inparanoid
Chimp	phosphatidylinositol-5-phosphate 4-kinase type 2 gamma
Mouse	phosphatidylinositol-5-phosphate 4-kinase, type II, gamma
Rat	phosphatidylinositol-5-phosphate 4-kinase type 2 gamma
Dog	phosphatidylinositol-5-phosphate 4-kinase type 2 gamma
Horse	phosphatidylinositol-5-phosphate 4-kinase type 2 gamma

Publication Statistics

PubMed Score 9.31

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PubTator Score 37.95

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Patents

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Related Publications

Text Mined References (15)

GeneRif Annotations (3)

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PMID	Year	Title