Tchem PIP4K2C Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma

Protein Summary

Description

May play an important role in the production of Phosphatidylinositol bisphosphate (PIP2), in the endoplasmic reticulum.

Uniprot Accession IDs

• Q8TBX8
• B2RDL3
• B4DM11
• B4DY44
• Q9H6N2

Gene Name

• PIP4K2C

Ensembl ID

• ENST00000354947
• ENSP00000347032
• ENSG00000166908
• ENST00000422156
• ENSP00000412035
• ENST00000540759
• ENSP00000439878
• ENST00000550465
• ENSP00000447390

Symbol

• PIP5K2C
• PIP5K2C

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.95
molecular function	0.93
kinase perturbation	0.88
histone modification site profile	0.74
interacting protein	0.74

Protein Classes

PANTHER Classes

Protein / Transferase / Kinase / Phosphatidylinositol 5-phosphate 4-kinase Type-2 Gamma

DTO Classes

Protein / Kinase / Non-protein Kinase / Lipid Kinase / Phosphatidylinositol 5-phosphate 4-kinase Type-2 Gamma

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.16   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 99   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.16   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 99   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 6

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0