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Tchem
PIP4K2B
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta

Protein Summary
Description
Participates in the biosynthesis of phosphatidylinositol 4,5-bisphosphate. The protein encoded by this gene catalyzes the phosphorylation of phosphatidylinositol-5-phosphate on the fourth hydroxyl of the myo-inositol ring to form phosphatidylinositol-5,4-bisphosphate. This gene is a member of the phosphatidylinositol-5-phosphate 4-kinase family. The encoded protein sequence does not show similarity to other kinases, but the protein does exhibit kinase activity. Additionally, the encoded protein interacts with p55 TNF receptor. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000613180
  • ENSP00000480776
  • ENSG00000277292
  • ENST00000619039
  • ENSP00000482548
  • ENSG00000276293

Symbol
  • PIP5K2B
  • PI5P4KB
  • PIP5K2B
  • PIP5KIIB
  • PIP5P4KB
  • PIP5KIIbeta
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.99
molecular function
0.96
small molecule
0.85
microRNA
0.79
virus perturbation
0.76


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.01   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 169   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.01   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 169   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1