You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
PINX1
PIN2/TERF1-interacting telomerase inhibitor 1

Protein Summary
Description
Microtubule-binding protein essential for faithful chromosome segregation. Mediates TRF1 and TERT accumulation in nucleolus and enhances TRF1 binding to telomeres. Inhibits telomerase activity. May inhibit cell proliferation and act as tumor suppressor.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000314787
  • ENSP00000318966
  • ENSG00000254093
  • ENST00000519088
  • ENSP00000428853

Symbol
  • LPTL
  • LPTS
  • Gno1
  • LPTL
  • LPTS
  • Pxr1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.9
trait
0.86
histone modification site profile
0.82
cellular component
0.81
biological process
0.66


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 193.5   (req: < 5)
Gene RIFs: 53   (req: <= 3)
Antibodies: 211   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 193.5   (req: >= 5)
Gene RIFs: 53   (req: > 3)
Antibodies: 211   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0