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Tbio
PINX1
PIN2/TERF1-interacting telomerase inhibitor 1

Protein Summary
Description
Microtubule-binding protein essential for faithful chromosome segregation. Mediates TRF1 and TERT accumulation in nucleolus and enhances TRF1 binding to telomeres. Inhibits telomerase activity. May inhibit cell proliferation and act as tumor suppressor.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000314787
  • ENSP00000318966
  • ENSG00000254093
  • ENST00000519088
  • ENSP00000428853

Symbol
  • LPTL
  • LPTS
  • Gno1
  • LPTL
  • LPTS
  • Pxr1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.9
trait
0.86
histone modification site profile
0.82
cellular component
0.81
biological process
0.66


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 193.5   (req: < 5)
Gene RIFs: 48   (req: <= 3)
Antibodies: 211   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 193.5   (req: >= 5)
Gene RIFs: 48   (req: > 3)
Antibodies: 211   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (181)
TERF1
Tbio
Family:  TF
Novelty:  0.00174529
p_int:  0.999999951
p_ni:  4.6e-8
p_wrong:  3e-9
Score:  0.898
Data Source:  BioPlex,STRINGDB
FBL
Tbio
Family:  Enzyme
Novelty:  0.00080634
p_int:  0.999060618
p_ni:  0.000939382
Score:  0.835
Data Source:  BioPlex,STRINGDB
NOCT
Tbio
Novelty:  0.01696096
p_int:  0.972707836
p_ni:  0.027290677
p_wrong:  0.000001488
Data Source:  BioPlex
FXR1
Tbio
Novelty:  0.01279428
p_int:  0.945056657
p_ni:  0.054943343
Score:  0.228
Data Source:  BioPlex,STRINGDB
FAM98A
Tbio
Novelty:  0.30067413
p_int:  0.924463354
p_ni:  0.075536646
Score:  0.26
Data Source:  BioPlex,STRINGDB
SNRNP70
Tbio
Novelty:  0.00116631
p_int:  0.91832747
p_ni:  0.081010601
p_wrong:  0.000661929
Score:  0.159
Data Source:  BioPlex,STRINGDB
EAF1
Tbio
Novelty:  0.81120425
p_int:  0.904524488
p_ni:  0.09512205
p_wrong:  0.000353462
Data Source:  BioPlex
WDYHV1
Tbio
Family:  Enzyme
Novelty:  0.1844203
p_int:  0.892385142
p_ni:  0.107316911
p_wrong:  0.000297947
Data Source:  BioPlex
DGCR8
Tbio
Novelty:  0.00271221
p_int:  0.857470847
p_ni:  0.1421385
p_wrong:  0.000390653
Data Source:  BioPlex
RPL8
Tbio
Novelty:  0.01064076
p_int:  0.80834217
p_ni:  0.19165783
Score:  0.176
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (83)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
22
15
24
2
97.9
neuroticism measurement
3
12
12
6.4
96.2
alkaline phosphatase measurement
2
2
1
16
92.9
low density lipoprotein cholesterol measurement
16
9
16
92.5
carotid artery intima media thickness
6
6
6
92.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
24
2
97.9
neuroticism measurement
12
6.4
96.2
alkaline phosphatase measurement
1
16
92.9
low density lipoprotein cholesterol measurement
16
92.5
carotid artery intima media thickness
6
92.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
PIN2/TERF1 interacting telomerase inhibitor 1
463987
Mouse
MGI:1919650
72400
Rat
RGD:1566025
305963
Dog
PIN2 (TERF1) interacting telomerase inhibitor 1
VGNC:44569
100856757
Horse
PIN2 (TERF1) interacting telomerase inhibitor 1
VGNC:21460
100054913
Species
Name
OMA
EggNOG
Inparanoid
Chimp
PIN2/TERF1 interacting telomerase inhibitor 1
Mouse
Rat
Dog
PIN2 (TERF1) interacting telomerase inhibitor 1
Horse
PIN2 (TERF1) interacting telomerase inhibitor 1
Publication Statistics
PubMed Score 193.50
PubMed score by year
PubTator Score 66.17
PubTator score by year
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Related Publications
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PMID
Year
Title