Tbio PINK1 Serine/threonine-protein kinase PINK1, mitochondrial

Protein Summary

Description

Protects against mitochondrial dysfunction during cellular stress by phosphorylating mitochondrial proteins. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy) by mediating activation and translocation of PRKN (PubMed:14607334, PubMed:15087508, PubMed:19229105, PubMed:19966284, PubMed:20404107, PubMed:20798600, PubMed:23620051, PubMed:23754282, PubMed:23933751, PubMed:24660806, PubMed:24751536, PubMed:24784582, PubMed:24896179, PubMed:25527291). Targets PRKN to dysfunctional depolarized mitochondria through the phosphorylation of MFN2 (PubMed:23620051). Activates PRKN in 2 steps: (1) by mediating phosphorylation at 'Ser-65' of PRKN and (2) mediating phosphorylation of ubiquitin, converting PRKN to its fully-active form (PubMed:24660806, PubMed:24751536, PubMed:24784582, PubMed:25527291). Required for ubiquinone reduction by mitochondrial complex I by mediating phosphorylation of complex I subunit NDUFA10 (By similarity). This gene encodes a serine/threonine protein kinase that localizes to mitochondria. It is thought to protect cells from stress-induced mitochondrial dysfunction. Mutations in this gene cause one form of autosomal recessive early-onset Parkinson disease. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9BXM7
• Q8N6T9
• Q8NBU3
• Q96DE4

Gene Name

• PINK1

Ensembl ID

• ENST00000321556
• ENSP00000364204
• ENSG00000158828

Symbol

• BRPK
• PARK6

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
molecular function	1
cellular component	0.88
kinase perturbation	0.81
PubMedID	0.81

Protein Classes

PANTHER Classes

Protein / Transferase / Kinase / Protein Kinase / Serine/threonine Protein Kinase Receptor / Serine/threonine-protein Kinase Pink1, Mitochondrial

Protein / Receptor / Protein Kinase Receptor / Serine/threonine Protein Kinase Receptor / Serine/threonine-protein Kinase Pink1, Mitochondrial

DTO Classes

Protein / Kinase / Protein Kinase / Other Group / Nkf2 Family / Serine/threonine-protein Kinase Pink1, Mitochondrial

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1499.65   (req: < 5)

Gene RIFs: 412   (req: <= 3)

Antibodies: 715   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1499.65   (req: >= 5)

Gene RIFs: 412   (req: > 3)

Antibodies: 715   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 82

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0