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Tchem
PIM1
Serine/threonine-protein kinase pim-1

Protein Summary
Description
Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation and thus providing a selective advantage in tumorigenesis. Exerts its oncogenic activity through: the regulation of MYC transcriptional activity, the regulation of cell cycle progression and by phosphorylation and inhibition of proapoptotic proteins (BAD, MAP3K5, FOXO3). Phosphorylation of MYC leads to an increase of MYC protein stability and thereby an increase of transcriptional activity. The stabilization of MYC exerted by PIM1 might explain partly the strong synergism between these two oncogenes in tumorigenesis. Mediates survival signaling through phosphorylation of BAD, which induces release of the anti-apoptotic protein Bcl-X(L)/BCL2L1. Phosphorylation of MAP3K5, an other proapoptotic protein, by PIM1, significantly decreases MAP3K5 kinase activity and inhibits MAP3K5-mediated phosphorylation of JNK and JNK/p38MAPK subsequently reducing caspase-3 activation and cell apoptosis. S ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000373509
  • ENSP00000362608
  • ENSG00000137193

Symbol
  • PIM
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
PubMedID
1
molecular function
0.98
virus perturbation
0.98
transcription factor binding site profile
0.96


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 207.3   (req: < 5)
Gene RIFs: 176   (req: <= 3)
Antibodies: 649   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 207.3   (req: >= 5)
Gene RIFs: 176   (req: > 3)
Antibodies: 649   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2684
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (94)
MARK3
Tchem
Family:  Kinase
Novelty:  0.01304552
p_int:  0.999988439
p_ni:  0.000011561
Score:  0.636
Data Source:  BioPlex,STRINGDB
DCP1B
Tdark
Novelty:  0.36605365
p_int:  0.999978026
p_ni:  0.000021974
Score:  0.875
Data Source:  BioPlex,STRINGDB
EDC3
Tbio
Novelty:  0.02077346
p_int:  0.999778636
p_ni:  0.000221364
Score:  0.871
Data Source:  BioPlex,STRINGDB
DCAF4
Tbio
Novelty:  0.24190895
p_int:  0.999157732
p_ni:  0.000842267
p_wrong:  1e-9
Score:  0.211
Data Source:  BioPlex,STRINGDB
DCP1A
Tbio
Novelty:  0.02038933
p_int:  0.970527453
p_ni:  0.029472547
Score:  0.869
Data Source:  BioPlex,STRINGDB
DDX6
Tbio
Family:  Enzyme
Novelty:  0.01032357
p_int:  0.936654222
p_ni:  0.063345778
Score:  0.873
Data Source:  BioPlex,STRINGDB
MYC
Tchem
Family:  TF
Novelty:  0.00005734
Score:  0.98
Data Source:  STRINGDB
NFATC1
Tchem
Family:  TF
Novelty:  0.00130337
Score:  0.966
Data Source:  STRINGDB
STAT3
Tchem
Family:  TF
Novelty:  0.00011808
Score:  0.952
Data Source:  STRINGDB
SND1
Tbio
Family:  Epigenetic
Novelty:  0.00949997
Score:  0.935
Data Source:  STRINGDB
Pathways (19)
Cytokine Signaling in Immune system (R-HSA-1280215)

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Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Interleukin-4 and Interleukin-13 signaling
Reactome
Signaling by Interleukins
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
Interleukin-4 and Interleukin-13 signaling
Signaling by Interleukins
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (24)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
1
1
1
75.5
mean reticulocyte volume
1
2
2
69.2
red blood cell distribution width
2
1
2
60.5
platelet count
1
1
1
24.3
monocyte percentage of leukocytes
1
1
1
12.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
1
75.5
mean reticulocyte volume
2
69.2
red blood cell distribution width
2
60.5
platelet count
1
24.3
monocyte percentage of leukocytes
1
12.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:97584
18712
Rat
RGD:3330
24649
Horse
Pim-1 proto-oncogene, serine/threonine kinase
VGNC:21456
100053898
Cow
Pim-1 proto-oncogene, serine/threonine kinase
VGNC:32899
281402
Pig
Pim-1 proto-oncogene, serine/threonine kinase
100157844
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Horse
Pim-1 proto-oncogene, serine/threonine kinase
Cow
Pim-1 proto-oncogene, serine/threonine kinase
Pig
Pim-1 proto-oncogene, serine/threonine kinase
Publication Statistics
PubMed Score 207.30
PubMed score by year
PubTator Score 589.62
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title