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Tbio
PILRA
Paired immunoglobulin-like type 2 receptor alpha

Protein Summary
Description
Paired receptors consist of highly related activating and inhibitory receptors and are widely involved in the regulation of the immune system. PILRA is thought to act as a cellular signaling inhibitory receptor by recruiting cytoplasmic phosphatases like PTPN6/SHP-1 and PTPN11/SHP-2 via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules. Receptor for PIANP. (Microbial infection) Acts as an entry co-receptor for herpes simplex virus 1. Cell signaling pathways rely on a dynamic interaction between activating and inhibiting processes. SHP-1-mediated dephosphorylation of protein tyrosine residues is central to the regulation of several cell signaling pathways. Two types of inhibitory receptor superfamily members are immunoreceptor tyrosine-based inhibitory motif (ITIM)-bearing receptors and their non-ITIM-bearing, activating counterparts. Control of cell signaling via SHP-1 is thought to occur through a balance between PILRalpha-mediated inhib ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000198536
  • ENSP00000198536
  • ENSG00000085514
  • ENST00000350573
  • ENSP00000340109
  • ENST00000394000
  • ENSP00000377569

Symbol
  • FDF03
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.92
cell type or tissue
0.81
tissue sample
0.68
protein domain
0.58
cell line
0.57


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.42   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 159   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.42   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 159   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (56)
B4GALNT4
Tdark
Family:  Enzyme
Novelty:  0.19278471
p_int:  0.999999262
p_ni:  7.37e-7
p_wrong:  1e-9
Score:  0.52
Data Source:  BioPlex,STRINGDB
NID2
Tbio
Novelty:  0.01638372
p_int:  0.99999918
p_ni:  8.2e-7
Score:  0.161
Data Source:  BioPlex,STRINGDB
PILRB
Tbio
Novelty:  0.19219511
p_int:  0.999998942
p_ni:  4e-9
p_wrong:  0.000001054
Data Source:  BioPlex
TRIM68
Tbio
Family:  Enzyme
Novelty:  0.11729189
p_int:  0.999993962
p_ni:  0.000006037
Score:  0.151
Data Source:  BioPlex,STRINGDB
LAMA4
Tbio
Novelty:  0.01288371
p_int:  0.999924269
p_ni:  0.000073681
p_wrong:  0.00000205
Score:  0.239
Data Source:  BioPlex,STRINGDB
B4GALNT3
Tbio
Family:  Enzyme
Novelty:  0.1822928
p_int:  0.999636747
p_ni:  0.000363252
Score:  0.52
Data Source:  BioPlex,STRINGDB
KIAA0319L
Tbio
Novelty:  0.02873675
p_int:  0.988610907
p_ni:  0.011389073
p_wrong:  2e-8
Score:  0.181
Data Source:  BioPlex,STRINGDB
LRRTM4
Tbio
Novelty:  0.07741851
p_int:  0.980204574
p_ni:  6.03e-7
p_wrong:  0.019794823
Score:  0.622
Data Source:  BioPlex,STRINGDB
PODXL
Tbio
Novelty:  0.00306913
p_int:  0.923147419
p_ni:  0.022333625
p_wrong:  0.054518956
Score:  0.205
Data Source:  BioPlex,STRINGDB
PTPN11
Tchem
Family:  Enzyme
Novelty:  0.00073124
Score:  0.907
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Immune System
Reactome
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Immune System
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (20)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hemoglobin measurement
2
3
3
93.8
platelet crit
2
2
2
89.1
blood metabolite measurement
2
1
4
87.3
platelet count
2
2
2
86.9
hematocrit
1
1
1
81.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hemoglobin measurement
3
93.8
platelet crit
2
89.1
blood metabolite measurement
4
87.3
platelet count
2
86.9
hematocrit
1
81.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
paired immunoglobin like type 2 receptor alpha
VGNC:8732
463597
Mouse
MGI:2450529
231805
Rat
RGD:6497409
100910669
Dog
paired immunoglobulin-like type 2 receptor alpha
489841
Cow
paired immunoglobulin-like type 2 receptor alpha
617785
Species
Name
OMA
EggNOG
Inparanoid
Chimp
paired immunoglobin like type 2 receptor alpha
Mouse
Rat
Dog
paired immunoglobulin-like type 2 receptor alpha
Cow
paired immunoglobulin-like type 2 receptor alpha
Publication Statistics
PubMed Score 18.42
PubMed score by year
PubTator Score 22.47
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title