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Tbio
PIK3R5
Phosphoinositide 3-kinase regulatory subunit 5

Protein Summary
Description
Regulatory subunit of the PI3K gamma complex. Required for recruitment of the catalytic subunit to the plasma membrane via interaction with beta-gamma G protein dimers. Required for G protein-mediated activation of PIK3CG (By similarity). Phosphatidylinositol 3-kinases (PI3Ks) phosphorylate the inositol ring of phosphatidylinositol at the 3-prime position, and play important roles in cell growth, proliferation, differentiation, motility, survival and intracellular trafficking. The PI3Ks are divided into three classes: I, II and III, and only the class I PI3Ks are involved in oncogenesis. This gene encodes the 101 kD regulatory subunit of the class I PI3K gamma complex, which is a dimeric enzyme, consisting of a 110 kD catalytic subunit gamma and a regulatory subunit of either 55, 87 or 101 kD. This protein recruits the catalytic subunit from the cytosol to the plasma membrane through high-affinity interaction with G-beta-gamma proteins. Multiple alternatively spliced transcript variant ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000447110
  • ENSP00000392812
  • ENSG00000141506
  • ENST00000581552
  • ENSP00000462433
  • ENST00000611902
  • ENSP00000477795
  • ENST00000616147
  • ENSP00000484211
  • ENST00000623421
  • ENSP00000485280

Symbol
  • p101
  • FOAP-2
  • P101-PI3K
  • F730038I15Rik
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
0.79
pathway
0.76
biological process
0.74
cellular component
0.67
tissue sample
0.58


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 82.2   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 395   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 82.2   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 395   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (122)
PIK3CG
Tclin
Family:  Kinase
Novelty:  0.00170533
Score:  0.986
Data Source:  Reactome,STRINGDB
GNG2
Tbio
Novelty:  0.04807242
Score:  0.979
Data Source:  Reactome,STRINGDB
GNB1
Tbio
Novelty:  0.02477955
Score:  0.978
Data Source:  Reactome,STRINGDB
PIK3R6
Tbio
Family:  Enzyme
Novelty:  0.28270718
Score:  0.966
Data Source:  STRINGDB
PIK3R3
Tbio
Family:  Enzyme
Novelty:  0.0136069
Score:  0.964
Data Source:  STRINGDB
PIK3CB
Tchem
Family:  Kinase
Novelty:  0.00390277
Score:  0.963
Data Source:  STRINGDB
PIK3R1
Tchem
Family:  Kinase
Novelty:  0.00179772
Score:  0.956
Data Source:  STRINGDB
PIK3R2
Tbio
Family:  Enzyme
Novelty:  0.00829659
Score:  0.956
Data Source:  STRINGDB
AKT1
Tchem
Family:  Kinase
Novelty:  0.00003185
Score:  0.949
Data Source:  STRINGDB
AKT3
Tchem
Family:  Kinase
Novelty:  0.00308931
Score:  0.944
Data Source:  STRINGDB
Nearest Tclin Targets (48)
Explore Nearest Tclin Targets
1 – 5 of 34
FGFR4
Tclin
Family:  Kinase
KEGG Distance:  1
Common Pathways:  1
FGFR3
Tclin
Family:  Kinase
KEGG Distance:  1
Common Pathways:  1
CSF1R
Tclin
Family:  Kinase
KEGG Distance:  1
Common Pathways:  1
JAK3
Tclin
Family:  Kinase
KEGG Distance:  1
Common Pathways:  2
IL2RA
Tclin
Family:  Other
KEGG Distance:  1
Common Pathways:  1
Pathways (228)
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) (R-HSA-9027276)

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Find Similar Targets
Items per page:
1 – 5 of 15
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
Reactome
G beta:gamma signalling through PI3Kgamma
Reactome
G-protein beta:gamma signalling
Reactome
GPCR downstream signalling
Reactome
GPVI-mediated activation cascade
Name
Explore in Pharos
Explore in Source
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
G beta:gamma signalling through PI3Kgamma
G-protein beta:gamma signalling
GPCR downstream signalling
GPVI-mediated activation cascade
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
5
1
1.5
97.3
Cleft palate
3
4
0
1.5
96.9
Oral cleft
3
3
2
1.4
94.3
autoimmune thyroid disease
1
1
0
1.1
50.8
mean fractional anisotropy measurement
1
1
1
50.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1.5
97.3
Cleft palate
0
1.5
96.9
Oral cleft
2
1.4
94.3
autoimmune thyroid disease
0
1.1
50.8
mean fractional anisotropy measurement
1
50.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
phosphoinositide-3-kinase regulatory subunit 5
VGNC:9521
455085
Macaque
phosphoinositide-3-kinase regulatory subunit 5
722027
Mouse
MGI:2443588
320207
Rat
RGD:1563261
497931
Dog
phosphoinositide-3-kinase regulatory subunit 5
VGNC:44562
612805
Species
Name
OMA
EggNOG
Inparanoid
Chimp
phosphoinositide-3-kinase regulatory subunit 5
Macaque
phosphoinositide-3-kinase regulatory subunit 5
Mouse
Rat
Dog
phosphoinositide-3-kinase regulatory subunit 5
Publication Statistics
PubMed Score 82.20
PubMed score by year
PubTator Score 28.12
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title