Tbio PIK3R4 Phosphoinositide 3-kinase regulatory subunit 4

Protein Summary

Description

Regulatory subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20643123).

Uniprot Accession IDs

• Q99570
• Q2TBF4
• PI3-kinase regulatory subunit 4

Gene Name

• PIK3R4

Ensembl ID

• ENST00000356763
• ENSP00000349205
• ENSG00000196455

Symbol

• VPS15
• p150
• VPS15

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	1
molecular function	0.91
biological process	0.83
disease perturbation	0.83
interacting protein	0.75

Protein Classes

DTO Classes

Protein / Kinase / Protein Kinase / Other Group / Vps15 Family / Phosphoinositide 3-kinase Regulatory Subunit 4

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 63.85   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 411   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 63.85   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 411   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0