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Tbio
PIK3R4
Phosphoinositide 3-kinase regulatory subunit 4

Protein Summary
Description
Regulatory subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20643123).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000356763
  • ENSP00000349205
  • ENSG00000196455

Symbol
  • VPS15
  • p150
  • VPS15
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
molecular function
0.91
biological process
0.83
disease perturbation
0.83
interacting protein
0.75


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55.12   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 411   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55.12   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 411   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (133)
NRBF2
Tbio
Novelty:  0.02432243
p_int:  0.999488369
p_ni:  0.000511631
Score:  0.93
Data Source:  BioPlex,STRINGDB
ATG14
Tbio
Novelty:  0.00914791
p_int:  0.998793241
p_ni:  0.001206759
Score:  0.998
Data Source:  BioPlex,Reactome,STRINGDB
RUBCNL
Tbio
Novelty:  0.20019585
p_int:  0.998789947
p_ni:  0.001210053
Score:  0.327
Data Source:  BioPlex,STRINGDB
JADE2
Tbio
Family:  Epigenetic
Novelty:  0.19820849
p_int:  0.96079704
p_ni:  0.03920296
Score:  0.252
Data Source:  BioPlex,STRINGDB
PIK3C3
Tchem
Family:  Kinase
Novelty:  0.00269825
Score:  0.999
Data Source:  Reactome,STRINGDB
BECN1
Tbio
Novelty:  0.0003792
Score:  0.999
Data Source:  Reactome,STRINGDB
UVRAG
Tbio
Novelty:  0.01081083
Score:  0.995
Data Source:  Reactome,STRINGDB
ATG13
Tbio
Novelty:  0.00951471
Score:  0.989
Data Source:  Reactome,STRINGDB
ATG5
Tbio
Novelty:  0.00081472
Score:  0.988
Data Source:  STRINGDB
ATG12
Tbio
Novelty:  0.00304298
Score:  0.988
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (53)
Autophagy (R-HSA-9612973)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 30
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Autophagy
Reactome
Cellular responses to external stimuli
Reactome
Cytokine Signaling in Immune system
Reactome
FLT3 Signaling
Reactome
IGF1R signaling cascade
Name
Explore in Pharos
Explore in Source
Autophagy
Cellular responses to external stimuli
Cytokine Signaling in Immune system
FLT3 Signaling
IGF1R signaling cascade
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.1
39.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
39.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
phosphoinositide-3-kinase regulatory subunit 4
VGNC:2511
460692
Mouse
MGI:1922919
75669
Rat
RGD:1311809
363131
Dog
phosphoinositide-3-kinase regulatory subunit 4
VGNC:44561
477064
Horse
phosphoinositide-3-kinase regulatory subunit 4
VGNC:21452
100052647
Species
Name
OMA
EggNOG
Inparanoid
Chimp
phosphoinositide-3-kinase regulatory subunit 4
Mouse
Rat
Dog
phosphoinositide-3-kinase regulatory subunit 4
Horse
phosphoinositide-3-kinase regulatory subunit 4
Publication Statistics
PubMed Score 55.12
PubMed score by year
PubTator Score 15.14
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title