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Tbio
PIK3R4
Phosphoinositide 3-kinase regulatory subunit 4

Protein Summary
Description
Regulatory subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20643123).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000356763
  • ENSP00000349205
  • ENSG00000196455

Symbol
  • VPS15
  • p150
  • VPS15
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
molecular function
0.91
biological process
0.83
disease perturbation
0.83
interacting protein
0.75


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 63.85   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 411   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 63.85   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 411   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0