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Tchem
PIK3R1
Phosphatidylinositol 3-kinase regulatory subunit alpha

Protein Summary
Description
Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling (PubMed:17626883, PubMed:19805105, PubMed:7518429). Modulates the cellular response to ER stress by promoting nuclear translocation of XBP1 isoform 2 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement (PubMed:20348923). Phosphatidylinositol 3-kinase phosphorylates the inositol ring of phosphatidylinositol at the 3-prime position. The enzyme comprises a 110 kD catalytic subunit and a regulatory subunit of either 85, 55, or 50 kD. This gene encode ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000320694
  • ENSP00000323512
  • ENSG00000145675
  • ENST00000336483
  • ENSP00000338554
  • ENST00000521381
  • ENSP00000428056
  • ENST00000521657
  • ENSP00000429277
  • ENST00000523872
  • ENSP00000430098

Symbol
  • GRB1
  • p85
  • AGM7
  • GRB1
  • IMD36
  • p85-ALPHA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
hub protein
1
interacting protein
1
transcription factor perturbation
1
kinase
0.99


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 627.55   (req: < 5)
Gene RIFs: 178   (req: <= 3)
Antibodies: 994   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 627.55   (req: >= 5)
Gene RIFs: 178   (req: > 3)
Antibodies: 994   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 62
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 4
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0