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Tclin
PIK3CG
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

Protein Summary
Description
Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Links G-protein coupled receptor activation to PIP3 production. Involved in immune, inflammatory and allergic responses. Modulates leukocyte chemotaxis to inflammatory sites and in response to chemoattractant agents. May control leukocyte polarization and migration by regulating the spatial accumulation of PIP3 and by regulating the organization of F-actin formation and integrin-based adhesion at the leading edge. Controls motility of dendritic cells. Together with PIK3CD is involved in natural killer (NK) cell development and migration towards the sites of inflammation. Participates in T-lymphocyte migration. ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000359195
  • ENSP00000352121
  • ENSG00000105851
  • ENST00000440650
  • ENSP00000392258
  • ENST00000496166
  • ENSP00000419260

Symbol
  • PI3K
  • PIK3
  • PI3CG
  • PI3Kgamma
  • p110gamma
  • p120-PI3K
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
protein domain
1
molecular function
0.99
hub protein
0.95
pathway
0.81


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 681.19   (req: < 5)
Gene RIFs: 308   (req: <= 3)
Antibodies: 890   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 681.19   (req: >= 5)
Gene RIFs: 308   (req: > 3)
Antibodies: 890   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 48
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 641
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4