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Tclin
PIK3CG
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

Protein Summary
Description
Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Links G-protein coupled receptor activation to PIP3 production. Involved in immune, inflammatory and allergic responses. Modulates leukocyte chemotaxis to inflammatory sites and in response to chemoattractant agents. May control leukocyte polarization and migration by regulating the spatial accumulation of PIP3 and by regulating the organization of F-actin formation and integrin-based adhesion at the leading edge. Controls motility of dendritic cells. Together with PIK3CD is involved in natural killer (NK) cell development and migration towards the sites of inflammation. Participates in T-lymphocyte migration. ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000359195
  • ENSP00000352121
  • ENSG00000105851
  • ENST00000440650
  • ENSP00000392258
  • ENST00000496166
  • ENSP00000419260

Symbol
  • PI3K
  • PIK3
  • PI3CG
  • PI3Kgamma
  • p110gamma
  • p120-PI3K
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
protein domain
1
molecular function
0.99
hub protein
0.95
pathway
0.81


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 600.44   (req: < 5)
Gene RIFs: 308   (req: <= 3)
Antibodies: 890   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 600.44   (req: >= 5)
Gene RIFs: 308   (req: > 3)
Antibodies: 890   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 48
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 503
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (224)
HRAS
Tchem
Family:  Enzyme
Novelty:  0.00008069
Score:  0.998
Data Source:  STRINGDB
KRAS
Tclin
Family:  Enzyme
Novelty:  0.00013856
Score:  0.993
Data Source:  STRINGDB
NRAS
Tchem
Family:  Enzyme
Novelty:  0.00080922
Score:  0.99
Data Source:  STRINGDB
PIK3R5
Tbio
Family:  Enzyme
Novelty:  0.0147283
Score:  0.986
Data Source:  Reactome,STRINGDB
PIK3R1
Tchem
Family:  Kinase
Novelty:  0.00179772
Score:  0.981
Data Source:  STRINGDB
AKT1
Tchem
Family:  Kinase
Novelty:  0.00003185
Score:  0.979
Data Source:  STRINGDB
PIK3R2
Tbio
Family:  Enzyme
Novelty:  0.00829659
Score:  0.978
Data Source:  STRINGDB
PIK3R3
Tbio
Family:  Enzyme
Novelty:  0.0136069
Score:  0.978
Data Source:  STRINGDB
PIK3R6
Tbio
Family:  Enzyme
Novelty:  0.28270718
Score:  0.972
Data Source:  Reactome,STRINGDB
PDPK1
Tchem
Family:  Kinase
Novelty:  0.00430458
Score:  0.968
Data Source:  STRINGDB
Nearest Tclin Targets (48)
Explore Nearest Tclin Targets
1 – 5 of 34
FGFR2
Tclin
Family:  Kinase
KEGG Distance:  1
Common Pathways:  1
MET
Tclin
Family:  Kinase
KEGG Distance:  1
Common Pathways:  1
PDGFRA
Tclin
Family:  Kinase
KEGG Distance:  1
Common Pathways:  2
KIT
Tclin
Family:  Kinase
KEGG Distance:  1
Common Pathways:  2
Pathways (88)
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) (R-HSA-9027276)

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Items per page:
1 – 5 of 15
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
Reactome
G beta:gamma signalling through PI3Kgamma
Reactome
G-protein beta:gamma signalling
Reactome
GPCR downstream signalling
Reactome
GPVI-mediated activation cascade
Name
Explore in Pharos
Explore in Source
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
G beta:gamma signalling through PI3Kgamma
G-protein beta:gamma signalling
GPCR downstream signalling
GPVI-mediated activation cascade
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (55)
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Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
UniProtKB
Traceable Author Statement (TAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Agents acting on the renin-angiotensin system use measurement
1
1
1
48.5
pulse pressure measurement
2
1
2
32.7
common carotid intimal medial thickness
1
1
1
31.4
eosinophil percentage of leukocytes
1
1
1
30.2
1
1
1
28.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Agents acting on the renin-angiotensin system use measurement
1
48.5
pulse pressure measurement
2
32.7
common carotid intimal medial thickness
1
31.4
eosinophil percentage of leukocytes
1
30.2
1
28.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
VGNC:4468
463649
Macaque
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
698857
Mouse
MGI:1353576
30955
Rat
RGD:1306468
298947
Dog
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
VGNC:44558
483266
Species
Name
OMA
EggNOG
Inparanoid
Chimp
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
Macaque
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
Mouse
Rat
Dog
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
Publication Statistics
PubMed Score 600.44
PubMed score by year
PubTator Score 202.08
PubTator score by year
Patents
Patents by year
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Related Publications
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PMID
Year
Title