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Tchem
PIK3C2A
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha

Protein Summary
Description
Generates phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) that act as second messengers. Has a role in several intracellular trafficking events. Functions in insulin signaling and secretion. Required for translocation of the glucose transporter SLC2A4/GLUT4 to the plasma membrane and glucose uptake in response to insulin-mediated RHOQ activation. Regulates insulin secretion through two different mechanisms: involved in glucose-induced insulin secretion downstream of insulin receptor in a pathway that involves AKT1 activation and TBC1D4/AS160 phosphorylation, and participates in the late step of insulin granule exocytosis probably in insulin granule fusion. Synthesizes PtdIns3P in response to insulin signaling. Functions in clathrin-coated endocytic vesicle formation and distribution. Regulates dynamin-independent endocytosis, probably by recruiting EEA1 to internalizing vesicles. In neurosecretory cells synthesizes PtdIns3P on large ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265970
  • ENSP00000265970
  • ENSG00000011405

Symbol
  • CPK
  • PI3-K-C2A
  • PI3K-C2alpha
  • PI3K-C2-alpha
  • PI3-K-C2(ALPHA)
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
drug perturbation
0.96
molecular function
0.96
kinase perturbation
0.93
co-expressed gene
0.89


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5273.98   (req: < 5)
Gene RIFs: 29   (req: <= 3)
Antibodies: 594   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5273.98   (req: >= 5)
Gene RIFs: 29   (req: > 3)
Antibodies: 594   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0