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Tchem
PIK3C2A
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha

Protein Summary
Description
Generates phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) that act as second messengers. Has a role in several intracellular trafficking events. Functions in insulin signaling and secretion. Required for translocation of the glucose transporter SLC2A4/GLUT4 to the plasma membrane and glucose uptake in response to insulin-mediated RHOQ activation. Regulates insulin secretion through two different mechanisms: involved in glucose-induced insulin secretion downstream of insulin receptor in a pathway that involves AKT1 activation and TBC1D4/AS160 phosphorylation, and participates in the late step of insulin granule exocytosis probably in insulin granule fusion. Synthesizes PtdIns3P in response to insulin signaling. Functions in clathrin-coated endocytic vesicle formation and distribution. Regulates dynamin-independent endocytosis, probably by recruiting EEA1 to internalizing vesicles. In neurosecretory cells synthesizes PtdIns3P on large ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265970
  • ENSP00000265970
  • ENSG00000011405

Symbol
  • CPK
  • PI3-K-C2A
  • PI3K-C2alpha
  • PI3K-C2-alpha
  • PI3-K-C2(ALPHA)
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
drug perturbation
0.96
molecular function
0.96
kinase perturbation
0.93
co-expressed gene
0.89


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4553   (req: < 5)
Gene RIFs: 29   (req: <= 3)
Antibodies: 594   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4553   (req: >= 5)
Gene RIFs: 29   (req: > 3)
Antibodies: 594   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (281)
STAMBPL1
Tbio
Family:  Enzyme
Novelty:  0.08532786
p_int:  0.999998986
p_ni:  0.000001014
Score:  0.795
Data Source:  BioPlex,STRINGDB
FAM136A
Tdark
Novelty:  0.4050275
p_int:  0.999996979
p_ni:  0.000003021
Data Source:  BioPlex
CLINT1
Tbio
Novelty:  0.00945381
p_int:  0.999963174
p_ni:  0.000036826
Score:  0.986
Data Source:  BioPlex,STRINGDB
STAMBP
Tchem
Novelty:  0.01543821
p_int:  0.99991797
p_ni:  0.00008203
Score:  0.659
Data Source:  BioPlex,STRINGDB
PICALM
Tbio
Novelty:  0.00800832
p_int:  0.99986396
p_ni:  0.000136033
p_wrong:  6e-9
Score:  0.971
Data Source:  BioPlex,STRINGDB
EIF5A2
Tbio
Novelty:  0.01527502
p_int:  0.999842883
p_ni:  0.000157056
p_wrong:  6.1e-8
Data Source:  BioPlex
QPRT
Tbio
Family:  Enzyme
Novelty:  0.00781554
p_int:  0.992959528
p_ni:  0.007040472
Score:  0.202
Data Source:  BioPlex,STRINGDB
CDC16
Tbio
Novelty:  0.00916715
p_int:  0.983888726
p_ni:  0.016111273
p_wrong:  2e-9
Score:  0.208
Data Source:  BioPlex,STRINGDB
C6orf141
Tdark
Novelty:  1.46022784
p_int:  0.948865312
p_ni:  0.051134687
p_wrong:  1e-9
Data Source:  BioPlex
CRYL1
Tbio
Family:  Enzyme
Novelty:  0.04513297
p_int:  0.936876521
p_ni:  0.063123478
Data Source:  BioPlex
Nearest Tclin Targets (6)
Explore Nearest Tclin Targets
Pathways (34)
Clathrin-mediated endocytosis (R-HSA-8856828)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Clathrin-mediated endocytosis
Reactome
Golgi Associated Vesicle Biogenesis
Reactome
Membrane Trafficking
Reactome
Metabolism
Reactome
Metabolism of lipids
Name
Explore in Pharos
Explore in Source
Clathrin-mediated endocytosis
Golgi Associated Vesicle Biogenesis
Membrane Trafficking
Metabolism
Metabolism of lipids
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (30)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intraocular pressure measurement
4
3
5
88.8
1
1
0
1.2
70.9
mean platelet volume
2
2
2
70.4
ganglion cell inner plexiform layer thickness measurement
1
1
1
59.8
platelet count
1
1
1
59
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intraocular pressure measurement
5
88.8
0
1.2
70.9
mean platelet volume
2
70.4
ganglion cell inner plexiform layer thickness measurement
1
59.8
platelet count
1
59
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha
VGNC:8190
451052
Macaque
phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha
697202
Mouse
MGI:1203729
18704
Rat
RGD:1310389
361632
Dog
phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha
VGNC:44551
485399
Species
Name
OMA
EggNOG
Inparanoid
Chimp
phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha
Macaque
phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha
Mouse
Rat
Dog
phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha
Publication Statistics
PubMed Score 4553.00
PubMed score by year
PubTator Score 1191.74
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title