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Tbio
PIH1D1
PIH1 domain-containing protein 1

Protein Summary
Description
Involved in the assembly of C/D box small nucleolar ribonucleoprotein (snoRNP) particles (PubMed:17636026). Recruits the SWI/SNF complex to the core promoter of rRNA genes and enhances pre-rRNA transcription (PubMed:22368283, PubMed:24036451). Mediates interaction of TELO2 with the R2TP complex which is necessary for the stability of MTOR and SMG1 (PubMed:20864032). Positively regulates the assembly and activity of the mTORC1 complex (PubMed:24036451).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262265
  • ENSP00000262265
  • ENSG00000104872
  • ENST00000596049
  • ENSP00000470445

Symbol
  • NOP17
  • Pih1
  • NOP17
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.96
kinase perturbation
0.81
transcription factor binding site profile
0.76
tissue sample
0.69
histone modification site profile
0.61


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.53   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 208   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.53   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 208   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (126)
UXT
Tbio
Novelty:  0.0272609
p_int:  0.999999712
p_ni:  2.88e-7
Score:  0.894
Data Source:  BioPlex,STRINGDB
LRCH3
Tdark
Novelty:  1.02650989
p_int:  0.999998186
p_ni:  0.000001814
Score:  0.21
Data Source:  BioPlex,STRINGDB
PDRG1
Tbio
Novelty:  0.09389276
p_int:  0.999978354
p_ni:  0.000021646
Score:  0.856
Data Source:  BioPlex,STRINGDB
URI1
Tbio
Family:  Enzyme
Novelty:  0.04265162
p_int:  0.999968472
p_ni:  0.000031528
Score:  0.821
Data Source:  BioPlex,STRINGDB
RPAP2
Tbio
Family:  Enzyme
Novelty:  0.03383659
p_int:  0.999945259
p_ni:  0.000054741
Score:  0.881
Data Source:  BioPlex,STRINGDB
Q6EEV4
Tbio
Family:  Enzyme
Novelty:  0.11413088
p_int:  0.999845001
p_ni:  0.000154999
Score:  0.766
Data Source:  BioPlex,STRINGDB
RPAP3
Tbio
Family:  Enzyme
Novelty:  0.02003375
p_int:  0.999760255
p_ni:  0.000239745
Score:  0.998
Data Source:  BioPlex,STRINGDB
POLR3A
Tbio
Family:  Enzyme
Novelty:  0.01508849
p_int:  0.999572413
p_ni:  0.000427587
Score:  0.68
Data Source:  BioPlex,STRINGDB
POLR3K
Tbio
Family:  Enzyme
Novelty:  0.07105011
p_int:  0.999492118
p_ni:  0.000028113
p_wrong:  0.00047977
Score:  0.727
Data Source:  BioPlex,STRINGDB
POLR2D
Tbio
Family:  Enzyme
Novelty:  0.11021614
p_int:  0.999298249
p_ni:  0.000700874
p_wrong:  8.77e-7
Score:  0.725
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (28)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (45)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum albumin measurement
7
11
13
99.1
blood protein measurement
10
13
18
96.4
hemoglobin measurement
5
6
6
92.7
sex hormone-binding globulin measurement
8
2
7
6.3
91.6
multiple sclerosis
2
2
0
1.1
89.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum albumin measurement
13
99.1
blood protein measurement
18
96.4
hemoglobin measurement
6
92.7
sex hormone-binding globulin measurement
7
6.3
91.6
multiple sclerosis
0
1.1
89.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
PIH1 domain containing 1
VGNC:2287
456205
Macaque
PIH1 domain containing 1
718787
Mouse
MGI:1916095
68845
Rat
RGD:1309809
292898
Dog
PIH1 domain containing 1
VGNC:44547
611943
Species
Name
OMA
EggNOG
Inparanoid
Chimp
PIH1 domain containing 1
Macaque
PIH1 domain containing 1
Mouse
Rat
Dog
PIH1 domain containing 1
Publication Statistics
PubMed Score 11.53
PubMed score by year
PubTator Score 4.97
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title