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Tbio
PIGU
Phosphatidylinositol glycan anchor biosynthesis class U protein

Protein Summary
Description
Component of the GPI transamidase complex. May be involved in the recognition of either the GPI attachment signal or the lipid portion of GPI. The protein encoded by this gene shares similarity with Saccharomyces cerevisiae Cdc91, a predicted integral membrane protein that may function in cell division control. The protein encoded by this gene is the fifth subunit of GPI transamidase that attaches GPI-anchors to proteins. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000217446
  • ENSP00000217446
  • ENSG00000101464
  • ENST00000374820
  • ENSP00000363953

Symbol
  • CDC91L1
  • GAB1
  • CDC91L1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.88
transcription factor
0.87
cellular component
0.84
transcription factor binding site profile
0.74
transcription factor perturbation
0.74


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.13   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 26   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.13   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 26   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (55)
THY1
Tbio
Novelty:  0.00032846
p_int:  0.994592335
p_ni:  0.005407665
Data Source:  BioPlex
VNN2
Tbio
Novelty:  0.02286648
p_int:  0.991795562
p_ni:  0.008204438
Data Source:  BioPlex
RTP2
Tbio
Novelty:  0.05972678
p_int:  0.975305288
p_ni:  0.024694645
p_wrong:  6.7e-8
Data Source:  BioPlex
ART4
Tbio
Family:  Enzyme
Novelty:  0.15332159
p_int:  0.973068191
p_ni:  0.026931752
p_wrong:  5.6e-8
Data Source:  BioPlex
SPPL2B
Tchem
Family:  Enzyme
Novelty:  0.0274774
p_int:  0.932996511
p_ni:  0.067003476
p_wrong:  1.4e-8
Data Source:  BioPlex
PIGK
Tbio
Family:  Enzyme
Novelty:  0.02333499
p_int:  0.92103562
p_ni:  0.078964328
p_wrong:  5.3e-8
Score:  0.999
Data Source:  BioPlex,STRINGDB
NECTIN4
Tclin
Novelty:  0.00694563
p_int:  0.908659674
p_ni:  0.091340175
p_wrong:  1.51e-7
Score:  0.173
Data Source:  BioPlex,STRINGDB
LYPD3
Tbio
Novelty:  0.03248533
p_int:  0.893044361
p_ni:  0.106955639
p_wrong:  1e-9
Data Source:  BioPlex
PIGT
Tbio
Family:  Enzyme
Novelty:  0.02539879
p_int:  0.831194318
p_ni:  0.168805549
p_wrong:  1.34e-7
Score:  0.999
Data Source:  BioPlex,STRINGDB
CTLA4
Tclin
Novelty:  0.00012781
p_int:  0.830297788
p_ni:  0.169701873
p_wrong:  3.39e-7
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Attachment of GPI anchor to uPAR (R-HSA-162791)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Attachment of GPI anchor to uPAR
Reactome
Metabolism of proteins
Reactome
Post-translational modification: synthesis of GPI-anchored proteins
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Attachment of GPI anchor to uPAR
Metabolism of proteins
Post-translational modification: synthesis of GPI-anchored proteins
Post-translational protein modification
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (8)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
HGNC
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Inferred by Curator (IC)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (24)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
3
6
10
98
glomerular filtration rate
4
4
4
95.6
3
2
0
1.8
90.8
suntan
1
1
1
88.4
sex hormone-binding globulin measurement
4
2
4
87.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
10
98
glomerular filtration rate
4
95.6
0
1.8
90.8
suntan
1
88.4
sex hormone-binding globulin measurement
4
87.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
phosphatidylinositol glycan anchor biosynthesis class U
VGNC:6238
458193
Mouse
MGI:3039607
228812
Rat
RGD:727825
353304
Dog
phosphatidylinositol glycan anchor biosynthesis class U
VGNC:44543
485846
Horse
phosphatidylinositol glycan anchor biosynthesis class U
VGNC:21435
100054427
Species
Name
OMA
EggNOG
Inparanoid
Chimp
phosphatidylinositol glycan anchor biosynthesis class U
Mouse
Rat
Dog
phosphatidylinositol glycan anchor biosynthesis class U
Horse
phosphatidylinositol glycan anchor biosynthesis class U
Publication Statistics
PubMed Score 8.13
PubMed score by year
PubTator Score 3.14
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title