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Tbio
PIGT
GPI transamidase component PIG-T

Protein Summary
Description
Component of the GPI transamidase complex. Essential for transfer of GPI to proteins, particularly for formation of carbonyl intermediates. This gene encodes a protein that is involved in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. This protein is an essential component of the multisubunit enzyme, GPI transamidase. GPI transamidase mediates GPI anchoring in the endoplasmic reticulum, by catalyzing the transfer of fully assembled GPI units to proteins. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000279035
  • ENSP00000279035
  • ENSG00000124155
  • ENST00000279036
  • ENSP00000279036
  • ENST00000372689
  • ENSP00000361774
  • ENST00000543458
  • ENSP00000441577
  • ENST00000545755
  • ENSP00000443963

Symbol
  • NDAP
  • PNH2
  • CGI-06
  • MCAHS3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.83
cell type or tissue
0.8
cellular component
0.8
disease perturbation
0.79
transcription factor binding site profile
0.76


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.81   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 141   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.81   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 141   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (66)
USP54
Tdark
Family:  Enzyme
Novelty:  0.31344498
p_int:  0.999977118
p_ni:  0.000022882
Data Source:  BioPlex
TNIP1
Tbio
Novelty:  0.0147254
p_int:  0.999957839
p_ni:  0.000042161
Data Source:  BioPlex
CEP85L
Tbio
Novelty:  0.23631446
p_int:  0.999937863
p_ni:  0.000028806
p_wrong:  0.000033331
Score:  0.188
Data Source:  BioPlex,STRINGDB
HOXC9
Tbio
Family:  TF
Novelty:  0.02524418
p_int:  0.999868407
p_ni:  0.000128752
p_wrong:  0.00000284
Score:  0.185
Data Source:  BioPlex,STRINGDB
RMND5B
Tbio
Novelty:  0.08447048
p_int:  0.999868117
p_ni:  0.000057518
p_wrong:  0.000074365
Score:  0.232
Data Source:  BioPlex,STRINGDB
GPAA1
Tbio
Novelty:  0.01874575
p_int:  0.999740416
p_ni:  0.000259584
Score:  0.999
Data Source:  BioPlex,STRINGDB
FAM136A
Tdark
Novelty:  0.4050275
p_int:  0.999074258
p_ni:  0.000925742
Data Source:  BioPlex
ZMYND19
Tdark
Novelty:  0.3590069
p_int:  0.998973876
p_ni:  0.001026123
p_wrong:  1e-9
Data Source:  BioPlex
ARMC8
Tbio
Novelty:  0.06820746
p_int:  0.996393025
p_ni:  0.003606975
Data Source:  BioPlex
HELZ
Tbio
Family:  Enzyme
Novelty:  0.08786982
p_int:  0.992357707
p_ni:  0.007642293
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Attachment of GPI anchor to uPAR (R-HSA-162791)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Attachment of GPI anchor to uPAR
Reactome
Metabolism of proteins
Reactome
Post-translational modification: synthesis of GPI-anchored proteins
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Attachment of GPI anchor to uPAR
Metabolism of proteins
Post-translational modification: synthesis of GPI-anchored proteins
Post-translational protein modification
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
1
1
1
15.8
free cholesterol measurement
1
1
1
15.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
1
15.8
free cholesterol measurement
1
15.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
phosphatidylinositol glycan anchor biosynthesis class T
VGNC:6237
458282
Macaque
phosphatidylinositol glycan anchor biosynthesis class T
710556
Mouse
MGI:1926178
78928
Rat
RGD:1307156
296360
Dog
phosphatidylinositol glycan anchor biosynthesis class T
VGNC:44542
477244
Species
Name
OMA
EggNOG
Inparanoid
Chimp
phosphatidylinositol glycan anchor biosynthesis class T
Macaque
phosphatidylinositol glycan anchor biosynthesis class T
Mouse
Rat
Dog
phosphatidylinositol glycan anchor biosynthesis class T
Publication Statistics
PubMed Score 43.81
PubMed score by year
PubTator Score 12.56
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title