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Tbio
PIGP
Phosphatidylinositol N-acetylglucosaminyltransferase subunit P

Protein Summary
Description
Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis. This gene encodes an enzyme involved in the first step of glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid found on many blood cells that serves to anchor proteins to the cell surface. The encoded protein is a component of the GPI-N-acetylglucosaminyltransferase complex that catalyzes the transfer of N-acetylglucosamine (GlcNAc) from UDP-GlcNAc to phosphatidylinositol (PI). This gene is located in the Down Syndrome critical region on chromosome 21 and is a candidate for the pathogenesis of Down syndrome. This gene has multiple pseudogenes and is a member of the phosphatidylinositol glycan anchor biosynthesis gene family. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Feb 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000360525
  • ENSP00000353719
  • ENSG00000185808
  • ENST00000399098
  • ENSP00000382049
  • ENST00000399102
  • ENSP00000382053
  • ENST00000399103
  • ENSP00000382054
  • ENST00000464265
  • ENSP00000420037

Symbol
  • DCRC
  • DSCR5
  • DSCRC
  • DCRC
  • DSRC
  • DSCR5
  • PIG-P
  • DCRC-S
  • EIEE55
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.9
virus perturbation
0.85
transcription factor binding site profile
0.82
cell type or tissue
0.78
kinase perturbation
0.66


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 81.98   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 114   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 81.98   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 114   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (58)
PYCARD
Tbio
Novelty:  0.00719985
p_int:  0.999876951
p_ni:  0.000123046
p_wrong:  3e-9
Score:  0.269
Data Source:  BioPlex,STRINGDB
COX4I1
Tbio
Family:  Enzyme
Novelty:  0.00208873
p_int:  0.985531437
p_ni:  3e-9
p_wrong:  0.01446856
Data Source:  BioPlex
PIGA
Tbio
Family:  Enzyme
Novelty:  0.00172769
p_int:  0.977728954
p_ni:  0.022271041
p_wrong:  5e-9
Score:  0.994
Data Source:  BioPlex,STRINGDB
PIGH
Tbio
Family:  Enzyme
Novelty:  0.0584561
p_int:  0.836992866
p_ni:  0.001149376
p_wrong:  0.161857758
Score:  0.995
Data Source:  BioPlex,STRINGDB
PIGC
Tbio
Family:  Enzyme
Novelty:  0.02057578
Score:  0.991
Data Source:  STRINGDB
DPM2
Tdark
Novelty:  0.04752556
Score:  0.989
Data Source:  STRINGDB
PIGQ
Tbio
Family:  Enzyme
Novelty:  0.02701629
Score:  0.982
Data Source:  STRINGDB
PIGL
Tbio
Family:  Enzyme
Novelty:  0.03151013
Score:  0.981
Data Source:  STRINGDB
PIGY
Tbio
Family:  Enzyme
Novelty:  0.17988252
Score:  0.979
Data Source:  STRINGDB
PYURF
Tdark
Novelty:  0.19841169
Score:  0.941
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Post-translational modification: synthesis of GPI-anchored proteins
Reactome
Post-translational protein modification
Reactome
Synthesis of glycosylphosphatidylinositol (GPI)
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Post-translational modification: synthesis of GPI-anchored proteins
Post-translational protein modification
Synthesis of glycosylphosphatidylinositol (GPI)
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eye color
1
1
1
42.3
birth weight
1
1
1
4.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eye color
1
42.3
birth weight
1
4.1
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
phosphatidylinositol glycan anchor biosynthesis class P
VGNC:3732
473990
Macaque
phosphatidylinositol glycan anchor biosynthesis class P
696305
Mouse
MGI:1860433
56176
Rat
RGD:1307205
288238
Dog
phosphatidylinositol glycan anchor biosynthesis class P
478413
Species
Name
OMA
EggNOG
Inparanoid
Chimp
phosphatidylinositol glycan anchor biosynthesis class P
Macaque
phosphatidylinositol glycan anchor biosynthesis class P
Mouse
Rat
Dog
phosphatidylinositol glycan anchor biosynthesis class P
Publication Statistics
PubMed Score 81.98
PubMed score by year
PubTator Score 15.00
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title