You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
PIGO
GPI ethanolamine phosphate transferase 3

Protein Summary
Description
Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the GPI third mannose which links the GPI-anchor to the C-terminus of the proteins by an amide bond. This gene encodes a protein that is involved in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid which contains three mannose molecules in its core backbone. The GPI-anchor is found on many blood cells and serves to anchor proteins to the cell surface. This protein is involved in the transfer of ethanolaminephosphate (EtNP) to the third mannose in GPI. At least three alternatively spliced transcripts encoding two distinct isoforms have been found for this gene. [provided by RefSeq, Jan 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000298004
  • ENSP00000298004
  • ENSG00000165282
  • ENST00000361778
  • ENSP00000354678
  • ENST00000378617
  • ENSP00000367880

Symbol
  • HPMRS2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.88
metabolite
0.73
transcription factor binding site profile
0.69
kinase perturbation
0.66
tissue sample
0.63


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.66   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 136   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.66   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 136   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (81)
POTEI
Tdark
Novelty:  0.41311202
p_int:  0.9997935
p_ni:  0.0002065
Score:  0.166
Data Source:  BioPlex,STRINGDB
ATP2B2
Tbio
Family:  Transporter
Novelty:  0.007782
p_int:  0.995943998
p_ni:  0.004056
p_wrong:  2e-9
Score:  0.187
Data Source:  BioPlex,STRINGDB
HTR3A
Tclin
Family:  IC
Novelty:  0.00217443
p_int:  0.985723619
p_ni:  0.014276381
Data Source:  BioPlex
PSCA
Tbio
Novelty:  0.00323778
p_int:  0.983850658
p_ni:  0.016149342
Data Source:  BioPlex
NKAIN1
Tdark
Family:  Enzyme
Novelty:  0.52190272
p_int:  0.979635389
p_ni:  0.020364611
Data Source:  BioPlex
ATP2A3
Tchem
Family:  Transporter
Novelty:  0.0090982
p_int:  0.965678583
p_ni:  0.034321417
Score:  0.205
Data Source:  BioPlex,STRINGDB
UPK1A
Tbio
Novelty:  0.01748122
p_int:  0.953973913
p_ni:  0.046026087
Data Source:  BioPlex
PTCHD3
Tbio
Novelty:  0.00081643
p_int:  0.94416343
p_ni:  0.05583657
Data Source:  BioPlex
HTR3C
Tchem
Family:  IC
Novelty:  0.112097
p_int:  0.906010891
p_ni:  0.093989096
p_wrong:  1.3e-8
Data Source:  BioPlex
ADGRG5
Tdark
Family:  GPCR
Novelty:  0.26575982
p_int:  0.890400635
p_ni:  0.109599333
p_wrong:  3.2e-8
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Post-translational modification: synthesis of GPI-anchored proteins
Reactome
Post-translational protein modification
Reactome
Synthesis of glycosylphosphatidylinositol (GPI)
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Post-translational modification: synthesis of GPI-anchored proteins
Post-translational protein modification
Synthesis of glycosylphosphatidylinositol (GPI)
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
2
2
2
48
platelet count
1
1
1
47.2
mean platelet volume
1
1
1
43.2
mean corpuscular volume
1
1
1
22.6
mean reticulocyte volume
1
1
1
19.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
2
48
platelet count
1
47.2
mean platelet volume
1
43.2
mean corpuscular volume
1
22.6
mean reticulocyte volume
1
19.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
phosphatidylinositol glycan anchor biosynthesis class O
698588
Mouse
MGI:1861452
56703
Rat
RGD:1309498
313341
Horse
phosphatidylinositol glycan anchor biosynthesis class O
VGNC:21429
100055801
Cow
phosphatidylinositol glycan anchor biosynthesis class O
VGNC:32874
783989
Species
Name
OMA
EggNOG
Inparanoid
Macaque
phosphatidylinositol glycan anchor biosynthesis class O
Mouse
Rat
Horse
phosphatidylinositol glycan anchor biosynthesis class O
Cow
phosphatidylinositol glycan anchor biosynthesis class O
Publication Statistics
PubMed Score 26.66
PubMed score by year
PubTator Score 5.83
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title