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Tbio
PIGM
GPI mannosyltransferase 1

Protein Summary
Description
Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the first alpha-1,4-mannose to GlcN-acyl-PI during GPI precursor assembly. This gene encodes a transmembrane protein that is located in the endoplasmic reticulum and is involved in GPI-anchor biosynthesis. The glycosylphosphatidylinositol (GPI)-anchor is a glycolipid which contains three mannose molecules in its core backbone. The GPI-anchor is found on many blood cells and serves to anchor proteins to the cell surface. This gene encodes a mannosyltransferase, GPI-MT-I, that transfers the first mannose to GPI on the lumenal side of the endoplasmic reticulum. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000368090
  • ENSP00000357069
  • ENSG00000143315

Symbol
  • GPI-MT-I
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.91
transcription factor perturbation
0.88
transcription factor binding site profile
0.83
metabolite
0.73
kinase perturbation
0.66


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.46   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 70   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.46   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 70   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (86)
STARD7
Tbio
Novelty:  0.04511594
p_int:  0.996986951
p_ni:  0.003013016
p_wrong:  3.2e-8
Score:  0.234
Data Source:  BioPlex,STRINGDB
OPALIN
Tdark
Novelty:  0.08221612
p_int:  0.947871122
p_ni:  0.051419045
p_wrong:  0.000709833
Data Source:  BioPlex
HTR3C
Tchem
Family:  IC
Novelty:  0.112097
p_int:  0.92332658
p_ni:  0.07667342
Data Source:  BioPlex
TM2D2
Tdark
Novelty:  0.10390283
p_int:  0.88046701
p_ni:  0.119532985
p_wrong:  6e-9
Score:  0.411
Data Source:  BioPlex,STRINGDB
UPK1A
Tbio
Novelty:  0.01748122
p_int:  0.876768888
p_ni:  0.123231112
Data Source:  BioPlex
POMK
Tbio
Family:  Kinase
Novelty:  0.09340344
p_int:  0.87425868
p_ni:  0.12574132
Score:  0.234
Data Source:  BioPlex,STRINGDB
CHRM4
Tclin
Family:  GPCR
Novelty:  0.00759817
p_int:  0.810470569
p_ni:  0.189529424
p_wrong:  8e-9
Data Source:  BioPlex
ADGRG5
Tdark
Family:  GPCR
Novelty:  0.26575982
p_int:  0.791944742
p_ni:  0.208051699
p_wrong:  0.000003559
Data Source:  BioPlex
CNDP1
Tbio
Family:  Enzyme
Novelty:  0.0102642
p_int:  0.779579445
p_ni:  0.21979261
p_wrong:  0.000627945
Score:  0.212
Data Source:  BioPlex,STRINGDB
HAVCR2
Tbio
Novelty:  0.00155885
p_int:  0.773994553
p_ni:  0.225357872
p_wrong:  0.000647575
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Metabolism of proteins (R-HSA-392499)

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Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Post-translational modification: synthesis of GPI-anchored proteins
Reactome
Post-translational protein modification
Reactome
Synthesis of glycosylphosphatidylinositol (GPI)
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Post-translational modification: synthesis of GPI-anchored proteins
Post-translational protein modification
Synthesis of glycosylphosphatidylinositol (GPI)
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
granulocyte count
1
3
3
90.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
granulocyte count
3
90.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
phosphatidylinositol glycan anchor biosynthesis class M
VGNC:6132
746576
Mouse
MGI:1914806
67556
Rat
RGD:71041
79112
Dog
phosphatidylinositol glycan anchor biosynthesis class M
VGNC:44537
100855863
Horse
phosphatidylinositol glycan anchor biosynthesis class M
VGNC:21427
100058075
Species
Name
OMA
EggNOG
Inparanoid
Chimp
phosphatidylinositol glycan anchor biosynthesis class M
Mouse
Rat
Dog
phosphatidylinositol glycan anchor biosynthesis class M
Horse
phosphatidylinositol glycan anchor biosynthesis class M
Publication Statistics
PubMed Score 44.46
PubMed score by year
PubTator Score 10.09
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title