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Tbio
PIGK
GPI-anchor transamidase

Protein Summary
Description
Mediates GPI anchoring in the endoplasmic reticulum, by replacing a protein's C-terminal GPI attachment signal peptide with a pre-assembled GPI. During this transamidation reaction, the GPI transamidase forms a carbonyl intermediate with the substrate protein. This gene encodes a member of the cysteine protease family C13 that is involved in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. This protein is a member of the multisubunit enzyme, GPI transamidase and is thought to be its enzymatic component. GPI transamidase mediates GPI anchoring in the endoplasmic reticulum, by catalyzing the transfer of fully assembled GPI units to proteins. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000370812
  • ENSP00000359848
  • ENSG00000142892

Symbol
  • GPI8
  • GPI8
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.94
histone modification site profile
0.9
transcription factor perturbation
0.88
gene perturbation
0.86
cell type or tissue
0.81


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.53   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 170   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.53   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 170   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (67)
GPAA1
Tbio
Novelty:  0.01874575
p_int:  0.991763982
p_ni:  0.008236018
Score:  0.999
Data Source:  BioPlex,STRINGDB
PIGU
Tbio
Novelty:  0.11800036
p_int:  0.92103562
p_ni:  0.078964328
p_wrong:  5.3e-8
Score:  0.999
Data Source:  BioPlex,STRINGDB
PIGT
Tbio
Family:  Enzyme
Novelty:  0.02539879
p_int:  0.900229422
p_ni:  0.099770578
Score:  0.999
Data Source:  BioPlex,STRINGDB
THY1
Tbio
Novelty:  0.00032846
p_int:  0.886487015
p_ni:  0.113512985
Data Source:  BioPlex
PIGS
Tdark
Family:  Enzyme
Novelty:  0.36443235
Score:  0.999
Data Source:  STRINGDB
PIGO
Tbio
Family:  Enzyme
Novelty:  0.05949164
Score:  0.988
Data Source:  STRINGDB
PGAP1
Tbio
Family:  Enzyme
Novelty:  0.04642526
Score:  0.938
Data Source:  STRINGDB
PIGF
Tbio
Novelty:  0.86627653
Score:  0.909
Data Source:  STRINGDB
PLAUR
Tchem
Family:  Enzyme
Novelty:  0.00087642
Score:  0.9
Data Source:  Reactome,STRINGDB
PIGM
Tbio
Family:  Enzyme
Novelty:  0.02186069
Score:  0.853
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Attachment of GPI anchor to uPAR (R-HSA-162791)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Attachment of GPI anchor to uPAR
Reactome
Metabolism of proteins
Reactome
Post-translational modification: synthesis of GPI-anchored proteins
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Attachment of GPI anchor to uPAR
Metabolism of proteins
Post-translational modification: synthesis of GPI-anchored proteins
Post-translational protein modification
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
3
4
2
1.1
95.2
circadian rhythm
6
3
3
1.1
85.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
2
1.1
95.2
circadian rhythm
3
1.1
85.9
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
phosphatidylinositol glycan anchor biosynthesis class K
VGNC:6131
456962
Macaque
phosphatidylinositol glycan anchor biosynthesis class K
706143
Mouse
MGI:1913863
329777
Rat
RGD:1306753
295543
Dog
phosphatidylinositol glycan anchor biosynthesis class K
VGNC:44535
479985
Species
Name
OMA
EggNOG
Inparanoid
Chimp
phosphatidylinositol glycan anchor biosynthesis class K
Macaque
phosphatidylinositol glycan anchor biosynthesis class K
Mouse
Rat
Dog
phosphatidylinositol glycan anchor biosynthesis class K
Publication Statistics
PubMed Score 45.53
PubMed score by year
PubTator Score 10.87
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Text