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Tbio
PIGH
Phosphatidylinositol N-acetylglucosaminyltransferase subunit H

Protein Summary
Description
Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis. This gene encodes an endoplasmic reticulum associated protein that is involved in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI anchor is a glycolipid found on many blood cells and which serves to anchor proteins to the cell surface. The protein encoded by this gene is a subunit of the GPI N-acetylglucosaminyl (GlcNAc) transferase that transfers GlcNAc to phosphatidylinositol (PI) on the cytoplasmic side of the endoplasmic reticulum. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000216452
  • ENSP00000216452
  • ENSG00000100564

Symbol
  • GPI-H
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.83
metabolite
0.73
tissue sample
0.66
tissue
0.61
kinase perturbation
0.54


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.18   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 138   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.18   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 138   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (56)
COX4I1
Tbio
Family:  Enzyme
Novelty:  0.00208873
p_int:  0.999939388
p_ni:  0.000060612
Data Source:  BioPlex
IL18RAP
Tbio
Novelty:  0.0141773
p_int:  0.999752038
p_ni:  0.00024796
p_wrong:  2e-9
Score:  0.485
Data Source:  BioPlex,STRINGDB
P2RX4
Tchem
Family:  IC
Novelty:  0.00242958
p_int:  0.999040372
p_ni:  0.00084138
p_wrong:  0.000118248
Score:  0.235
Data Source:  BioPlex,STRINGDB
ARSE
Tbio
Family:  Enzyme
Novelty:  0.00151862
p_int:  0.949363165
p_ni:  0.002162535
p_wrong:  0.048474299
Data Source:  BioPlex
PIGP
Tbio
Family:  Enzyme
Novelty:  0.01400934
p_int:  0.836992866
p_ni:  0.001149376
p_wrong:  0.161857758
Score:  0.995
Data Source:  BioPlex,STRINGDB
TMEM63C
Tdark
Family:  IC
Novelty:  0.02849254
p_int:  0.789938885
p_ni:  0.001238148
p_wrong:  0.208822966
Data Source:  BioPlex
PIGA
Tbio
Family:  Enzyme
Novelty:  0.00172769
Score:  0.998
Data Source:  STRINGDB
PIGC
Tbio
Family:  Enzyme
Novelty:  0.02057578
Score:  0.996
Data Source:  STRINGDB
PIGQ
Tbio
Family:  Enzyme
Novelty:  0.02701629
Score:  0.99
Data Source:  STRINGDB
PIGL
Tbio
Family:  Enzyme
Novelty:  0.03151013
Score:  0.988
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Post-translational modification: synthesis of GPI-anchored proteins
Reactome
Post-translational protein modification
Reactome
Synthesis of glycosylphosphatidylinositol (GPI)
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Post-translational modification: synthesis of GPI-anchored proteins
Post-translational protein modification
Synthesis of glycosylphosphatidylinositol (GPI)
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum metabolite measurement
2
3
9
92.6
glycerophospholipid measurement
1
1
3
85.1
blood metabolite measurement
1
1
3
85.1
2
1
0
1.1
59.8
diastolic blood pressure
1
1
1
36.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum metabolite measurement
9
92.6
glycerophospholipid measurement
3
85.1
blood metabolite measurement
3
85.1
0
1.1
59.8
diastolic blood pressure
1
36.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
phosphatidylinositol glycan anchor biosynthesis class H
VGNC:3360
736276
Macaque
phosphatidylinositol glycan anchor biosynthesis class H
710780
Mouse
MGI:99463
110417
Rat
RGD:1311438
362756
Dog
phosphatidylinositol glycan anchor biosynthesis class H
VGNC:44534
611566
Species
Name
OMA
EggNOG
Inparanoid
Chimp
phosphatidylinositol glycan anchor biosynthesis class H
Macaque
phosphatidylinositol glycan anchor biosynthesis class H
Mouse
Rat
Dog
phosphatidylinositol glycan anchor biosynthesis class H
Publication Statistics
PubMed Score 18.18
PubMed score by year
PubTator Score 4.67
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title