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Tbio
PIGC
Phosphatidylinositol N-acetylglucosaminyltransferase subunit C

Protein Summary
Description
Involved in GPI anchor biosynthesis (PubMed:8806613, PubMed:27694521). Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis (ECO:0000269|PubMed:27694521). This gene encodes an endoplasmic reticulum associated protein that is involved in glycosylphosphatidylinositol (GPI) lipid anchor biosynthesis. The GPI lipid anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. The encoded protein is one subunit of the GPI N-acetylglucosaminyl (GlcNAc) transferase that transfers GlcNAc to phosphatidylinositol (PI) on the cytoplasmic side of the endoplasmic reticulum. Two alternatively spliced transcripts that encode the same protein have been found for this gene. A pseudogene on chromosome 11 has also been characterized. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000344529
  • ENSP00000356701
  • ENSG00000135845
  • ENST00000367728
  • ENSP00000356702

Symbol
  • GPI2
  • GPI2
  • MRT62
  • GPIBD16
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.97
virus perturbation
0.9
transcription factor binding site profile
0.85
transcription factor perturbation
0.8
disease perturbation
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.32   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 75   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.32   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 75   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (83)
PIGA
Tbio
Family:  Enzyme
Novelty:  0.00172769
Score:  0.996
Data Source:  STRINGDB
PIGH
Tbio
Family:  Enzyme
Novelty:  0.0584561
Score:  0.996
Data Source:  STRINGDB
PIGQ
Tbio
Family:  Enzyme
Novelty:  0.02701629
Score:  0.994
Data Source:  STRINGDB
PIGP
Tbio
Family:  Enzyme
Novelty:  0.01400934
Score:  0.991
Data Source:  STRINGDB
DPM2
Tdark
Novelty:  0.04752556
Score:  0.989
Data Source:  STRINGDB
PIGL
Tbio
Family:  Enzyme
Novelty:  0.03151013
Score:  0.987
Data Source:  STRINGDB
PIGY
Tbio
Family:  Enzyme
Novelty:  0.17988252
Score:  0.974
Data Source:  STRINGDB
PYURF
Tdark
Novelty:  0.19841169
Score:  0.928
Data Source:  STRINGDB
PIGB
Tbio
Family:  Enzyme
Novelty:  0.05237713
Score:  0.911
Data Source:  STRINGDB
PIGM
Tbio
Family:  Enzyme
Novelty:  0.02186069
Score:  0.877
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Post-translational modification: synthesis of GPI-anchored proteins
Reactome
Post-translational protein modification
Reactome
Synthesis of glycosylphosphatidylinositol (GPI)
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Post-translational modification: synthesis of GPI-anchored proteins
Post-translational protein modification
Synthesis of glycosylphosphatidylinositol (GPI)
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (22)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
10
17
32
98.7
waist-hip ratio
6
14
17
97.5
red blood cell distribution width
4
3
4
96.7
hip circumference
2
10
12
96.2
heel bone mineral density
1
3
3
93.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
32
98.7
waist-hip ratio
17
97.5
red blood cell distribution width
4
96.7
hip circumference
12
96.2
heel bone mineral density
3
93.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
phosphatidylinositol glycan anchor biosynthesis class C
705657
Mouse
MGI:1914542
67292
Rat
RGD:1311337
364032
Dog
phosphatidylinositol glycan anchor biosynthesis class C
VGNC:44531
480073
Cow
phosphatidylinositol glycan anchor biosynthesis class C
510483
Species
Name
OMA
EggNOG
Inparanoid
Macaque
phosphatidylinositol glycan anchor biosynthesis class C
Mouse
Rat
Dog
phosphatidylinositol glycan anchor biosynthesis class C
Cow
phosphatidylinositol glycan anchor biosynthesis class C
Publication Statistics
PubMed Score 51.32
PubMed score by year
PubTator Score 13.94
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title