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Tbio
PIGA
Phosphatidylinositol N-acetylglucosaminyltransferase subunit A

Protein Summary
Description
Necessary for the synthesis of N-acetylglucosaminyl-phosphatidylinositol, the very early intermediate in GPI-anchor biosynthesis. This gene encodes a protein required for synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the biosynthetic pathway of GPI anchor. The GPI anchor is a glycolipid found on many blood cells and which serves to anchor proteins to the cell surface. Paroxysmal nocturnal hemoglobinuria, an acquired hematologic disorder, has been shown to result from mutations in this gene. Alternate splice variants have been characterized. A related pseudogene is located on chromosome 12. [provided by RefSeq, Jun 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000333590
  • ENSP00000369820
  • ENSG00000165195
  • ENST00000482148
  • ENSP00000489528
  • ENST00000542278
  • ENSP00000442653
  • ENST00000634582
  • ENSP00000489540

Symbol
  • GPI3
  • PNH1
  • PIG-A
  • MCAHS2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.88
virus perturbation
0.76
metabolite
0.73
cellular component
0.7
microRNA
0.7


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 622.61   (req: < 5)
Gene RIFs: 23   (req: <= 3)
Antibodies: 181   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 622.61   (req: >= 5)
Gene RIFs: 23   (req: > 3)
Antibodies: 181   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (101)
COX4I1
Tbio
Family:  Enzyme
Novelty:  0.00208873
p_int:  0.999995483
p_ni:  0.000004517
Data Source:  BioPlex
IL18RAP
Tbio
Novelty:  0.0141773
p_int:  0.999989092
p_ni:  0.000010908
Score:  0.219
Data Source:  BioPlex,STRINGDB
DPEP1
Tclin
Family:  Enzyme
Novelty:  0.00384946
p_int:  0.999916938
p_ni:  0.000083062
Data Source:  BioPlex
TRAF1
Tbio
Novelty:  0.00526776
p_int:  0.999873244
p_ni:  0.000126756
Data Source:  BioPlex
EVA1C
Tbio
Novelty:  0.45928677
p_int:  0.994147664
p_ni:  0.005852332
p_wrong:  4e-9
Score:  0.158
Data Source:  BioPlex,STRINGDB
THBS2
Tbio
Novelty:  0.00310724
p_int:  0.986956731
p_ni:  0.013043269
Data Source:  BioPlex
NAGK
Tbio
Family:  Kinase
Novelty:  0.01603908
p_int:  0.984886427
p_ni:  0.015113568
p_wrong:  5e-9
Data Source:  BioPlex
PIGP
Tbio
Family:  Enzyme
Novelty:  0.01400934
p_int:  0.977728954
p_ni:  0.022271041
p_wrong:  5e-9
Score:  0.994
Data Source:  BioPlex,STRINGDB
PI4K2A
Tbio
Family:  Kinase
Novelty:  0.03506675
p_int:  0.97574947
p_ni:  0.024250233
p_wrong:  2.97e-7
Data Source:  BioPlex
CD79B
Tclin
Novelty:  0.00227414
p_int:  0.974875435
p_ni:  0.025124544
p_wrong:  2.1e-8
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Post-translational modification: synthesis of GPI-anchored proteins
Reactome
Post-translational protein modification
Reactome
Synthesis of glycosylphosphatidylinositol (GPI)
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Post-translational modification: synthesis of GPI-anchored proteins
Post-translational protein modification
Synthesis of glycosylphosphatidylinositol (GPI)
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vascular endothelial growth factor D measurement
1
2
0
1.6
76.7
sex hormone-binding globulin measurement
4
2
4
70.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vascular endothelial growth factor D measurement
0
1.6
76.7
sex hormone-binding globulin measurement
4
70.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
phosphatidylinositol glycan anchor biosynthesis class A
VGNC:2910
465507
Macaque
phosphatidylinositol glycan anchor biosynthesis class A
712514
Mouse
MGI:99461
18700
Rat
RGD:1589723
363464
Horse
phosphatidylinositol glycan anchor biosynthesis class A
VGNC:21420
100055827
Species
Name
OMA
EggNOG
Inparanoid
Chimp
phosphatidylinositol glycan anchor biosynthesis class A
Macaque
phosphatidylinositol glycan anchor biosynthesis class A
Mouse
Rat
Horse
phosphatidylinositol glycan anchor biosynthesis class A
Publication Statistics
PubMed Score 622.61
PubMed score by year
PubTator Score 102.15
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title