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Tbio
PIF1
ATP-dependent DNA helicase PIF1

Protein Summary
Description
DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA ends. Releases telomerase by unwinding the short telomerase RNA/telomeric DNA hybrid that is the intermediate in the telomerase reaction. Possesses an intrinsic strand annealing activity. This gene encodes a DNA-dependent adenosine triphosphate (ATP)-metabolizing enzyme that functions as a 5' to 3' DNA helicase. The encoded protein can resolve G-quadruplex structures and RNA-DNA hybrids at the ends of chromosomes. It also prevents telom ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000268043
  • ENSP00000268043
  • ENSG00000140451
  • ENST00000333425
  • ENSP00000328174
  • ENST00000559239
  • ENSP00000452792

Symbol
  • C15orf20
  • PIF
  • C15orf20
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
kinase perturbation
0.71
tissue sample
0.68
biological process
0.67
histone modification site profile
0.66


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 261.29   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 96   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 261.29   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 96   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (162)
SSSCA1
Tdark
Novelty:  0.53523038
p_int:  0.999998693
p_ni:  0.000001303
p_wrong:  4e-9
Score:  0.187
Data Source:  BioPlex,STRINGDB
KCTD12
Tchem
Novelty:  0.0386637
p_int:  0.999998546
p_ni:  0.000001426
p_wrong:  2.8e-8
Data Source:  BioPlex
ATP23
Tbio
Family:  Enzyme
Novelty:  0.09823059
p_int:  0.998085913
p_ni:  0.000869502
p_wrong:  0.001044584
Data Source:  BioPlex
ANKHD1
Tbio
Novelty:  0.05390096
p_int:  0.997596031
p_ni:  0.002403969
Data Source:  BioPlex
GMNN
Tbio
Novelty:  0.00436572
p_int:  0.981806367
p_ni:  0.018183564
p_wrong:  0.000010069
Score:  0.161
Data Source:  BioPlex,STRINGDB
DCAF11
Tbio
Novelty:  0.08318661
p_int:  0.951756644
p_ni:  0.048243356
Data Source:  BioPlex
PPP2R2D
Tbio
Family:  Enzyme
Novelty:  0.0658328
p_int:  0.918382304
p_ni:  0.081617696
Data Source:  BioPlex
PASK
Tchem
Family:  Kinase
Novelty:  0.14004084
p_int:  0.905850759
p_ni:  0.094149241
Data Source:  BioPlex
DICER1
Tbio
Family:  Enzyme
Novelty:  0.000306
p_int:  0.855314828
p_ni:  0.144685172
Data Source:  BioPlex
RCOR3
Tdark
Family:  TF
Novelty:  0.18886215
p_int:  0.839864469
p_ni:  0.160135526
p_wrong:  5e-9
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (20)
Find Similar Targets
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HGNC
Inferred from Direct Assay (IDA)
HGNC
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
HGNC
Inferred from Direct Assay (IDA)
HGNC
Inferred from Direct Assay (IDA)
HGNC
Inferred from Electronic Annotation (IEA)
UniProtKB-UniRule
Inferred from Electronic Annotation (IEA)
UniProtKB-UniRule
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
5
5
5
3.4
97.6
mean platelet volume
2
2
2
86.7
platelet crit
1
2
2
74.8
electrocardiography
1
1
1
21.5
pulse pressure measurement
1
1
1
12.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
5
3.4
97.6
mean platelet volume
2
86.7
platelet crit
2
74.8
electrocardiography
1
21.5
pulse pressure measurement
1
12.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
PIF1 5'-to-3' DNA helicase
VGNC:7390
453508
Macaque
PIF1 5'-to-3' DNA helicase
707914
Mouse
MGI:2143057
208084
Rat
RGD:1586053
367645
Dog
PIF1 5'-to-3' DNA helicase
VGNC:44530
100856387
Species
Name
OMA
EggNOG
Inparanoid
Chimp
PIF1 5'-to-3' DNA helicase
Macaque
PIF1 5'-to-3' DNA helicase
Mouse
Rat
Dog
PIF1 5'-to-3' DNA helicase
Publication Statistics
PubMed Score 261.29
PubMed score by year
PubTator Score 248.57
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title