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Tbio
PIBF1
Progesterone-induced-blocking factor 1

Protein Summary
Description
Plays a role in ciliogenesis. Isoform 1: Pericentriolar protein required to maintain mitotic spindle pole integrity (PubMed:21224392). Required for the centrosomal accumulation of PCM1 and the recruitment of centriolar satellite proteins such as BBS4. Via association with PCM1 may be involved in primary cilia formation (PubMed:23110211). Required for CEP63 centrosomal localization and its interaction with WDR62. Together with CEP63 promotes centriole duplication. Promotes the centrosomal localization of CDK2 (PubMed:26297806). Isoform 4: The secreted form is a mediator of progesterone that by acting on the phospholipase A2 enzyme interferes with arachidonic acid metabolism, induces a Th2 biased immune response, and by controlling decidual naturakl killer cells (NK) activity exerts an anti-abortive effect (PubMed:14634107, PubMed:3863495, PubMed:12516630). Increases the production of Th2-type cytokines by signaling via the JAK/STAT pathway. Activates STAT6 and inhibits STAT4 phosphoryla ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000326291
  • ENSP00000317144
  • ENSG00000083535
  • ENST00000615625
  • ENSP00000483286

Symbol
  • C13orf24
  • PIBF
  • PIBF
  • CEP90
  • JBTS33
  • C13orf24
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.87
cell type or tissue
0.8
virus perturbation
0.72
transcription factor binding site profile
0.62
trait
0.61


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.24   (req: < 5)
Gene RIFs: 25   (req: <= 3)
Antibodies: 276   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.24   (req: >= 5)
Gene RIFs: 25   (req: > 3)
Antibodies: 276   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (59)
TSNAXIP1
Tdark
Novelty:  0.50007311
p_int:  0.999999556
p_ni:  4.44e-7
Score:  0.197
Data Source:  BioPlex,STRINGDB
BFSP1
Tbio
Novelty:  0.01519136
p_int:  0.9999989
p_ni:  0.000001099
p_wrong:  1e-9
Data Source:  BioPlex
VAT1L
Tdark
Family:  Enzyme
Novelty:  0.45114244
p_int:  0.999996608
p_ni:  0.000003392
Score:  0.332
Data Source:  BioPlex,STRINGDB
CPNE2
Tdark
Novelty:  0.24188419
p_int:  0.999989447
p_ni:  0.000010553
Data Source:  BioPlex
LRRCC1
Tdark
Novelty:  0.14730953
p_int:  0.999701194
p_ni:  0.000298806
Score:  0.204
Data Source:  BioPlex,STRINGDB
ODF2
Tbio
Novelty:  0.03203587
p_int:  0.998756687
p_ni:  0.001228866
p_wrong:  0.000014446
Data Source:  BioPlex
EXOC3
Tbio
Novelty:  0.01051955
p_int:  0.998596421
p_ni:  0.001403579
Score:  0.185
Data Source:  BioPlex,STRINGDB
TXLNA
Tbio
Novelty:  0.02549959
p_int:  0.99805012
p_ni:  0.001949747
p_wrong:  1.33e-7
Data Source:  BioPlex
BORCS6
Tdark
Novelty:  0.83789033
p_int:  0.996451533
p_ni:  0.003548441
p_wrong:  2.6e-8
Data Source:  BioPlex
SLC25A41
Tdark
Family:  Transporter
Novelty:  1.04918395
p_int:  0.994316592
p_ni:  0.005683398
p_wrong:  1.1e-8
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (2)
Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Genes related to primary cilium development (based on CRISPR)
WikiPathways
Joubert Syndrome
Name
Explore in Pharos
Explore in Source
Genes related to primary cilium development (based on CRISPR)
Joubert Syndrome
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (19)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte percentage of leukocytes
2
2
2
77.8
mean corpuscular volume
1
1
1
72.6
mean reticulocyte volume
1
1
1
71.2
neutrophil count
2
2
2
59.4
red blood cell density measurement
1
1
1
56.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte percentage of leukocytes
2
77.8
mean corpuscular volume
1
72.6
mean reticulocyte volume
1
71.2
neutrophil count
2
59.4
red blood cell density measurement
1
56.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
progesterone immunomodulatory binding factor 1
VGNC:5096
452596
Mouse
MGI:1261910
52023
Rat
RGD:1305077
306104
Dog
progesterone immunomodulatory binding factor 1
VGNC:44523
476945
Horse
progesterone immunomodulatory binding factor 1
VGNC:21415
100065926
Species
Name
OMA
EggNOG
Inparanoid
Chimp
progesterone immunomodulatory binding factor 1
Mouse
Rat
Dog
progesterone immunomodulatory binding factor 1
Horse
progesterone immunomodulatory binding factor 1
Publication Statistics
PubMed Score 27.24
PubMed score by year
PubTator Score 64.42
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title