Tbio PIAS4 E3 SUMO-protein ligase PIAS4

Protein Summary

Description

Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53/TP53 pathway, the Wnt pathway and the steroid hormone signaling pathway. Involved in gene silencing. Mediates sumoylation of CEBPA, PARK7, HERC2, MYB, TCF4 and RNF168. In Wnt signaling, represses LEF1 and enhances TCF4 transcriptional activities through promoting their sumoylations. Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation.

Uniprot Accession IDs

• Q8N2W9
• O75926
• Q96G19
• Q9UN16

Gene Name

• PIAS4

Ensembl ID

• ENST00000262971
• ENSP00000262971
• ENSG00000105229

Symbol

• PIASG
• PIASY
• Piasg
• ZMIZ6
• PIAS-gamma

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
hub protein	0.96
biological process	0.84
molecular function	0.76
transcription factor	0.73
transcription factor binding site profile	0.73

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 72.58   (req: < 5)

Gene RIFs: 45   (req: <= 3)

Antibodies: 336   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 72.58   (req: >= 5)

Gene RIFs: 45   (req: > 3)

Antibodies: 336   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (206)

Explore Interacting Targets

1 – 10 of 206

• See Interactions on String-DB

CA10

Tbio

Family:  Enzyme

Novelty:  0.01053152

p_int:  0.999999223

p_ni:  2.1e-8

p_wrong:  7.56e-7

Score:  0.309

Data Source:  BioPlex,STRINGDB

RAD54L2

Tdark

Family:  Enzyme

Novelty:  0.26668341

p_int:  0.999997739

p_ni:  0.000002244

p_wrong:  1.7e-8

Score:  0.196

Data Source:  BioPlex,STRINGDB

ZCCHC12

Tbio

Novelty:  0.16283891

p_int:  0.999972746

p_ni:  1.24e-7

p_wrong:  0.00002713

Data Source:  BioPlex

RREB1

Tbio

Family:  TF

Novelty:  0.01394277

p_int:  0.999854413

p_ni:  0.000129204

p_wrong:  0.000016383

Data Source:  BioPlex

ZMYM1

Tdark

Novelty:  0.3860445

p_int:  0.999744979

p_ni:  0.000255021

Data Source:  BioPlex

SLX4

Tbio

Family:  Enzyme

Novelty:  0.01677273

p_int:  0.999276664

p_ni:  0.000022635

p_wrong:  0.000700701

Score:  0.165

Data Source:  BioPlex,STRINGDB

SIMC1

Tbio

Novelty:  0.39770049

p_int:  0.999237966

p_ni:  0.000762034

Data Source:  BioPlex

SETX

Tbio

Family:  Enzyme

Novelty:  0.00474094

p_int:  0.999089217

p_ni:  0.000910783

Data Source:  BioPlex

ATF7IP

Tbio

Novelty:  0.04269323

p_int:  0.99897908

p_ni:  0.001019497

p_wrong:  0.000001423

Data Source:  BioPlex

KDM5C

Tchem

Family:  TF; Epigenetic

Novelty:  0.00701855

p_int:  0.997920697

p_ni:  0.002079198

p_wrong:  1.05e-7

Data Source:  BioPlex

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (160)

Reactome (28)

KEGG (4)

PathwayCommons (6)

UniProt (1)

WikiPathways (121)

Cell Cycle (R-HSA-1640170)

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1 – 5 of 28

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Cell Cycle	597 targets	R-HSA-1640170
Reactome	Cell Cycle Checkpoints	272 targets	R-HSA-69620
Reactome	DNA Double Strand Break Response	58 targets	R-HSA-5693606
Reactome	DNA Double-Strand Break Repair	146 targets	R-HSA-5693532
Reactome	DNA Repair	306 targets	R-HSA-73894

Name	Explore in Pharos	Explore in Source
Cell Cycle	597 targets	R-HSA-1640170
Cell Cycle Checkpoints	272 targets	R-HSA-69620
DNA Double Strand Break Response	58 targets	R-HSA-5693606
DNA Double-Strand Break Repair	146 targets	R-HSA-5693532
DNA Repair	306 targets	R-HSA-73894

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (24)

Functions (7)

Components (6)

Processes (11)

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10

1 – 7 of 7

GO Term	Evidence	Assigned by
SUMO ligase activity	Inferred from Direct Assay (IDA)	BHF-UCL
ubiquitin protein ligase binding	Inferred from Physical Interaction (IPI)	BHF-UCL
SUMO transferase activity	Inferred from Mutant Phenotype (IMP)	UniProtKB
zinc ion binding	Non-traceable Author Statement (NAS)	UniProtKB
DNA binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
protein C-terminus binding	Inferred from Electronic Annotation (IEA)	Ensembl
transcription corepressor activity	Inferred from Electronic Annotation (IEA)	Ensembl

Disease Associations (null)

No disease associations found

GWAS Traits (22)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 22

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mean corpuscular volume	EFO_0004526	1	2	2		87.9
red blood cell density measurement	EFO_0007978	1	1	1		86.7
body mass index	EFO_0004340	3	3	3		84.6
mean reticulocyte volume	EFO_0010701	1	2	2		84.6
erythrocyte count	EFO_0004305	1	1	1		79

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mean corpuscular volume	EFO_0004526	2		87.9
red blood cell density measurement	EFO_0007978	1		86.7
body mass index	EFO_0004340	3		84.6
mean reticulocyte volume	EFO_0010701	2		84.6
erythrocyte count	EFO_0004305	1		79

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UniProt Keyword Find Similar Targets

No Header	No Header
Acetylation
Complete proteome
DNA-binding
Isopeptide bond
Metal-binding
Nucleus
Reference proteome
Repressor
Transcription
Transcription regulation

GWAS Trait Find Similar Targets

No Header	No Header
blood protein measurement
body height
body mass index
chronic lymphocytic leukemia
cigarettes per day measurement
creatinine measurement
eosinophil count
eosinophil percentage of leukocytes
erythrocyte count
glomerular filtration rate

MGI Phenotype Find Similar Targets

No Header	No Header
hematopoietic system phenotype
immune system phenotype
mortality/aging

IDG Resources

No IDG generated resources found

Orthologs (11)

1 – 5 of 11

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	protein inhibitor of activated STAT 4	VGNC:2295	736762
Macaque	protein inhibitor of activated STAT 4		714328
Mouse	protein inhibitor of activated STAT 4	MGI:2136940	59004
Rat	protein inhibitor of activated STAT, 4	RGD:1308737	362827
Dog	protein inhibitor of activated STAT 4	VGNC:44522	485049

Species	Name	OMA	EggNOG	Inparanoid
Chimp	protein inhibitor of activated STAT 4
Macaque	protein inhibitor of activated STAT 4
Mouse	protein inhibitor of activated STAT 4
Rat	protein inhibitor of activated STAT, 4
Dog	protein inhibitor of activated STAT 4

Publication Statistics

PubMed Score 72.58

PubMed score by year

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PubTator Score 59.96

PubTator score by year

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Related Publications

Text Mined References (76)

GeneRif Annotations (45)

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PMID	Year	Title