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Tbio
PIANP
PILR alpha-associated neural protein

Protein Summary
Description
Acts as a ligand for PILRA in neural tissues, where it may be involved in immune regulation. This gene encodes a ligand for the paired immunoglobin-like type 2 receptor alpha, and so may be involved in immune regulation. Alternate splicing results in multiple transcript variants encoding different proteins. [provided by RefSeq, Sep 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000320591
  • ENSP00000317818
  • ENSG00000139200
  • ENST00000534837
  • ENSP00000443919
  • ENST00000540656
  • ENSP00000442157

Symbol
  • C12orf53
  • PANP
  • PANP
  • LEDA1
  • leda-1
  • C12orf53
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.67
kinase perturbation
0.6
tissue sample
0.58
cell type or tissue
0.55
cell line
0.49


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 60.68   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 102   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 60.68   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 102   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (35)
GALNT4
Tbio
Family:  Enzyme
Novelty:  0.05200323
p_int:  0.999999622
p_ni:  3.78e-7
Score:  0.188
Data Source:  BioPlex,STRINGDB
ADCY9
Tbio
Family:  Enzyme
Novelty:  0.00744116
p_int:  0.999923809
p_ni:  0.000076191
Score:  0.169
Data Source:  BioPlex,STRINGDB
GALNT12
Tbio
Family:  Enzyme
Novelty:  0.085131
p_int:  0.999722411
p_ni:  0.000277589
Data Source:  BioPlex
PRUNE1
Tchem
Novelty:  0.02136836
p_int:  0.999473279
p_ni:  0.000526721
Score:  0.189
Data Source:  BioPlex,STRINGDB
AKT3
Tchem
Family:  Kinase
Novelty:  0.00308931
p_int:  0.999037769
p_ni:  0.000947426
p_wrong:  0.000014805
Score:  0.214
Data Source:  BioPlex,STRINGDB
CARMIL1
Tbio
Novelty:  0.04162135
p_int:  0.997343297
p_ni:  0.002656399
p_wrong:  3.05e-7
Score:  0.241
Data Source:  BioPlex,STRINGDB
PTPRD
Tbio
Family:  Enzyme
Novelty:  0.01059407
p_int:  0.99161352
p_ni:  0.007773915
p_wrong:  0.000612565
Score:  0.194
Data Source:  BioPlex,STRINGDB
TCAF2
Tbio
Family:  Enzyme
Novelty:  0.37070492
p_int:  0.987182821
p_ni:  0.012813356
p_wrong:  0.000003823
Data Source:  BioPlex
GALNT2
Tchem
Family:  Enzyme
Novelty:  0.02458542
p_int:  0.840210945
p_ni:  0.159789055
Score:  0.193
Data Source:  BioPlex,STRINGDB
PTPRF
Tchem
Family:  Enzyme
Novelty:  0.01017327
p_int:  0.771032652
p_ni:  0.228967348
Score:  0.177
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Immune System
Reactome
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Immune System
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
5
2
9
86.1
high density lipoprotein cholesterol measurement
1
2
2
79.2
mean corpuscular volume
1
1
1
57.3
red blood cell distribution width
1
1
1
56.8
triglyceride measurement
1
1
1
53.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
9
86.1
high density lipoprotein cholesterol measurement
2
79.2
mean corpuscular volume
1
57.3
red blood cell distribution width
1
56.8
triglyceride measurement
1
53.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
PILR alpha associated neural protein
VGNC:13338
451791
Mouse
MGI:2441908
319352
Rat
RGD:1304952
312711
Dog
PILR alpha associated neural protein
VGNC:44518
611639
Horse
PILR alpha associated neural protein
VGNC:21410
100052384
Species
Name
OMA
EggNOG
Inparanoid
Chimp
PILR alpha associated neural protein
Mouse
Rat
Dog
PILR alpha associated neural protein
Horse
PILR alpha associated neural protein
Publication Statistics
PubMed Score 60.68
PubMed score by year
PubTator Score 15.52
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title