PI4KB
Phosphatidylinositol 4-kinase beta
Protein Summary
Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate (PIP). May regulate Golgi disintegration/reorganization during mitosis, possibly via its phosphorylation. Involved in Golgi-to-plasma membrane trafficking (By similarity).
- ENST00000368872
- ENSP00000357866
- ENSG00000143393
- ENST00000368873
- ENSP00000357867
- ENST00000368874
- ENSP00000357868
- ENST00000529142
- ENSP00000433149
- PIK4CB
- NPIK
- PI4K92
- PIK4CB
- PI4KBETA
- PI4K-BETA
- PI4KIIIBETA
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
molecular function | 0.91 | ||
protein domain | 0.85 | ||
transcription factor perturbation | 0.84 | ||
disease perturbation | 0.83 | ||
ligand (protein) perturbation | 0.83 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 127.93 (req: < 5)
Gene RIFs: 32 (req: <= 3)
Antibodies: 124 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 127.93 (req: >= 5)
Gene RIFs: 32 (req: > 3)
Antibodies: 124 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 44
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (44)
Protein-Protein Interactions (156)
DNAJC10
Novelty: 0.02258366
p_int: 0.999999566
p_ni: 4.32e-7
p_wrong: 2e-9
Score: 0.223
Data Source: BioPlex,STRINGDB
CASP1
Family: Enzyme
Novelty: 0.00034643
p_int: 0.999999422
p_ni: 5.76e-7
p_wrong: 2e-9
Score: 0.3
Data Source: BioPlex,STRINGDB
RDM1
Novelty: 0.09585781
p_int: 0.999998931
p_ni: 0.000001069
Score: 0.455
Data Source: BioPlex,STRINGDB
CDK7
Family: Kinase
Novelty: 0.00322814
p_int: 0.99999293
p_ni: 0.00000707
Score: 0.215
Data Source: BioPlex,STRINGDB
KBTBD7
Novelty: 0.4947466
p_int: 0.999970128
p_ni: 0.000029864
p_wrong: 8e-9
Data Source: BioPlex
Nearest Tclin Targets (5)
Upstream (2)
Downstream (3)
1 – 2 of 2
Pathways (12)
Reactome (5)
KEGG (3)
PathwayCommons (4)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Metabolism | ||||
Reactome | Metabolism of lipids | ||||
Reactome | PI Metabolism | ||||
Reactome | Phospholipid metabolism | ||||
Reactome | Synthesis of PIPs at the Golgi membrane | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Metabolism | ||||
Metabolism of lipids | ||||
PI Metabolism | ||||
Phospholipid metabolism | ||||
Synthesis of PIPs at the Golgi membrane | ||||
Viral Interactions (0)
Gene Ontology Terms (16)
Functions (3)
Components (8)
Processes (5)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (8)
Items per page:
1 – 5 of 8
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
red blood cell distribution width | 2 | 2 | 2 | 66.8 | |||||
vitamin D measurement | 1 | 1 | 1 | 59 | |||||
lymphocyte count | 1 | 1 | 1 | 29 | |||||
gut microbiome measurement | 1 | 1 | 0 | 5.6 | 21.5 | ||||
glomerular filtration rate | 1 | 1 | 1 | 11.4 | |||||
Items per page:
1 – 5 of 8
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
red blood cell distribution width | 2 | 66.8 | |||||
vitamin D measurement | 1 | 59 | |||||
lymphocyte count | 1 | 29 | |||||
gut microbiome measurement | 0 | 5.6 | 21.5 | ||||
glomerular filtration rate | 1 | 11.4 | |||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Macaque | phosphatidylinositol 4-kinase beta | 710104 | ||||||
Mouse | MGI:1334433 | 107650 | ||||||
Rat | RGD:621214 | 81747 | ||||||
Dog | phosphatidylinositol 4-kinase beta | VGNC:44517 | 483196 | |||||
Horse | phosphatidylinositol 4-kinase beta | VGNC:21409 | 100055429 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Macaque | phosphatidylinositol 4-kinase beta | |||||
Mouse | ||||||
Rat | ||||||
Dog | phosphatidylinositol 4-kinase beta | |||||
Horse | phosphatidylinositol 4-kinase beta | |||||
Publication Statistics
PubMed Score 127.93
PubMed score by year
PubTator Score 33.91
PubTator score by year
Patents
Patents by year
Related Publications
Text Mined References (55)
GeneRif Annotations (32)
Items per page:
0 of 0
PMID | Year | Title |
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