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Tbio
PI4K2A
Phosphatidylinositol 4-kinase type 2-alpha

Protein Summary
Description
Membrane-bound phosphatidylinositol-4 kinase (PI4-kinase) that catalyzes the phosphorylation of phosphatidylinositol (PI) to phosphatidylinositol 4-phosphate (PI4P), a lipid that plays important roles in endocytosis, Golgi function, protein sorting and membrane trafficking and is required for prolonged survival of neurons. Besides, phosphorylation of phosphatidylinositol (PI) to phosphatidylinositol 4-phosphate (PI4P) is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3). Phosphatidylinositolpolyphosphates (PtdInsPs) are centrally involved in many biologic processes, ranging from cell growth and organization of the actin cytoskeleton to endo- and exocytosis. PI4KII phosphorylates PtdIns at the D-4 position, an essential step in the biosynthesis of PtdInsPs (Barylko et al., 2001 [PubMed 11244087]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000370631
  • ENSP00000359665
  • ENSG00000155252

Symbol
  • PI4KII
  • PIK42A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.97
transcription factor perturbation
0.84
disease perturbation
0.83
cellular component
0.78
kinase perturbation
0.76


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.56   (req: < 5)
Gene RIFs: 26   (req: <= 3)
Antibodies: 167   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.56   (req: >= 5)
Gene RIFs: 26   (req: > 3)
Antibodies: 167   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (172)
GABARAPL1
Tbio
Novelty:  0.00212657
p_int:  0.999997544
p_ni:  5.7e-8
p_wrong:  0.000002399
Score:  0.162
Data Source:  BioPlex,STRINGDB
GABARAP
Tbio
Novelty:  0.00444901
p_int:  0.999994995
p_ni:  0.000004921
p_wrong:  8.4e-8
Score:  0.181
Data Source:  BioPlex,STRINGDB
TSPAN3
Tbio
Novelty:  0.06362133
p_int:  0.999975832
p_ni:  0.000024164
p_wrong:  4e-9
Score:  0.187
Data Source:  BioPlex,STRINGDB
ANKRD13D
Tdark
Novelty:  2.14380936
p_int:  0.999849578
p_ni:  0.000150313
p_wrong:  1.09e-7
Data Source:  BioPlex
TMEM231
Tbio
Novelty:  0.17100188
p_int:  0.999826597
p_ni:  0.000173398
p_wrong:  5e-9
Score:  0.163
Data Source:  BioPlex,STRINGDB
TMEM206
Tdark
Novelty:  0.17311172
p_int:  0.999363506
p_ni:  0.000636493
p_wrong:  1e-9
Data Source:  BioPlex
PVR
Tbio
Novelty:  0.00215811
p_int:  0.999300563
p_ni:  0.00065699
p_wrong:  0.000042446
Score:  0.157
Data Source:  BioPlex,STRINGDB
IRGC
Tbio
Family:  Enzyme
Novelty:  0.10743948
p_int:  0.999255615
p_ni:  0.00069217
p_wrong:  0.000052214
Score:  0.177
Data Source:  BioPlex,STRINGDB
MBLAC2
Tdark
Family:  Enzyme
Novelty:  0.47407992
p_int:  0.998959619
p_ni:  0.000958677
p_wrong:  0.000081704
Data Source:  BioPlex
ANKRD13A
Tbio
Novelty:  0.61940334
p_int:  0.998672649
p_ni:  0.001327351
Data Source:  BioPlex
Nearest Tclin Targets (6)
Explore Nearest Tclin Targets
Pathways (71)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
PI Metabolism
Reactome
Phospholipid metabolism
Reactome
Synthesis of PIPs at the Golgi membrane
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of lipids
PI Metabolism
Phospholipid metabolism
Synthesis of PIPs at the Golgi membrane
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
metabolite measurement
1
1
1
55.2
blood metabolite measurement
1
1
1
40.7
amino acid measurement
1
1
1
40.7
protein measurement
1
1
1
40.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
metabolite measurement
1
55.2
blood metabolite measurement
1
40.7
amino acid measurement
1
40.7
protein measurement
1
40.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
phosphatidylinositol 4-kinase type 2 alpha
VGNC:12425
450656
Mouse
MGI:1934031
84095
Rat
RGD:620485
114554
Dog
phosphatidylinositol 4-kinase type 2 alpha
486824
Horse
phosphatidylinositol 4-kinase type 2 alpha
100070680
Species
Name
OMA
EggNOG
Inparanoid
Chimp
phosphatidylinositol 4-kinase type 2 alpha
Mouse
Rat
Dog
phosphatidylinositol 4-kinase type 2 alpha
Horse
phosphatidylinositol 4-kinase type 2 alpha
Publication Statistics
PubMed Score 27.56
PubMed score by year
PubTator Score 14.97
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
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PMID
Year
Title