Tbio PI4K2A Phosphatidylinositol 4-kinase type 2-alpha

Protein Summary

Description

Membrane-bound phosphatidylinositol-4 kinase (PI4-kinase) that catalyzes the phosphorylation of phosphatidylinositol (PI) to phosphatidylinositol 4-phosphate (PI4P), a lipid that plays important roles in endocytosis, Golgi function, protein sorting and membrane trafficking and is required for prolonged survival of neurons. Besides, phosphorylation of phosphatidylinositol (PI) to phosphatidylinositol 4-phosphate (PI4P) is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3). Phosphatidylinositolpolyphosphates (PtdInsPs) are centrally involved in many biologic processes, ranging from cell growth and organization of the actin cytoskeleton to endo- and exocytosis. PI4KII phosphorylates PtdIns at the D-4 position, an essential step in the biosynthesis of PtdInsPs (Barylko et al., 2001 [PubMed 11244087]).[supplied by OMIM, Mar 2008]

Uniprot Accession IDs

• Q9BTU6
• D3DR59
• Q9NSG8

Gene Name

• PI4K2A

Ensembl ID

• ENST00000370631
• ENSP00000359665
• ENSG00000155252

Symbol

• PI4KII
• PIK42A

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.97
transcription factor perturbation	0.84
disease perturbation	0.83
cellular component	0.78
kinase perturbation	0.76

Protein Classes

PANTHER Classes

Protein / Transferase / Kinase / Phosphatidylinositol 4-kinase Type 2-alpha

DTO Classes

Protein / Kinase / Non-protein Kinase / Lipid Kinase / Pi3/pi4 Kinase Family / Type Ii Pi4k Subfamily / Phosphatidylinositol 4-kinase Type 2-alpha

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.75   (req: < 5)

Gene RIFs: 30   (req: <= 3)

Antibodies: 167   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.75   (req: >= 5)

Gene RIFs: 30   (req: > 3)

Antibodies: 167   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0