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Tdark
PHYHIP
Phytanoyl-CoA hydroxylase-interacting protein

Protein Summary
Description
Its interaction with PHYH suggests a role in the development of the central system.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000321613
  • ENSP00000320017
  • ENSG00000168490
  • ENST00000454243
  • ENSP00000415491

Symbol
  • DYRK1AP3
  • KIAA0273
  • PAHX-AP
  • PAHXAP1
  • DYRK1AP3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.6
gene perturbation
0.49
tissue
0.44
histone modification site profile
0.4
cell line
0.39


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.1   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 102   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.1   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 102   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (66)
KIF15
Tchem
Novelty:  0.01328603
p_int:  0.999956642
p_ni:  0.000043358
Score:  0.516
Data Source:  BioPlex,STRINGDB
CA10
Tbio
Family:  Enzyme
Novelty:  0.01053152
p_int:  0.99958049
p_ni:  0.000171509
p_wrong:  0.000248
Score:  0.536
Data Source:  BioPlex,STRINGDB
LIMD1
Tbio
Novelty:  0.04868333
p_int:  0.999527483
p_ni:  0.000472456
p_wrong:  6.1e-8
Score:  0.71
Data Source:  BioPlex,STRINGDB
PRKD2
Tchem
Family:  Kinase
Novelty:  0.03143723
p_int:  0.998900958
p_ni:  0.001099042
Score:  0.226
Data Source:  BioPlex,STRINGDB
ANKRD12
Tbio
Novelty:  0.13114331
p_int:  0.998332033
p_ni:  0.001579811
p_wrong:  0.000088156
Score:  0.199
Data Source:  BioPlex,STRINGDB
PAQR5
Tbio
Novelty:  0.05821975
p_int:  0.987254947
p_ni:  0.012653197
p_wrong:  0.000091856
Score:  0.622
Data Source:  BioPlex,STRINGDB
TMEM255B
Tdark
Novelty:  1.57149427
p_int:  0.987254947
p_ni:  0.012653197
p_wrong:  0.000091856
Score:  0.269
Data Source:  BioPlex,STRINGDB
TRIP6
Tbio
Novelty:  0.02183202
p_int:  0.899895923
p_ni:  0.100103566
p_wrong:  5.11e-7
Score:  0.26
Data Source:  BioPlex,STRINGDB
PTRH2
Tbio
Family:  Enzyme
Novelty:  0.02494576
p_int:  0.770389769
p_ni:  0.229146338
p_wrong:  0.000463893
Score:  0.163
Data Source:  BioPlex,STRINGDB
PHYH
Tbio
Family:  Enzyme
Novelty:  0.00277669
Score:  0.892
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (0)
No GO Terms found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
2
3
63
1
1
0
1.1
29
frailty measurement
1
1
1
1.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
63
0
1.1
29
frailty measurement
1
1.9
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
phytanoyl-CoA 2-hydroxylase interacting protein
VGNC:2455
472710
Macaque
phytanoyl-CoA 2-hydroxylase interacting protein
715990
Mouse
MGI:1860417
105653
Dog
phytanoyl-CoA 2-hydroxylase interacting protein
VGNC:44512
100856493
Horse
phytanoyl-CoA 2-hydroxylase interacting protein
VGNC:21405
100056996
Species
Name
OMA
EggNOG
Inparanoid
Chimp
phytanoyl-CoA 2-hydroxylase interacting protein
Macaque
phytanoyl-CoA 2-hydroxylase interacting protein
Mouse
Dog
phytanoyl-CoA 2-hydroxylase interacting protein
Horse
phytanoyl-CoA 2-hydroxylase interacting protein
Publication Statistics
PubMed Score 4.10
PubMed score by year
PubTator Score 2.24
PubTator score by year
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Related Publications
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PMID
Year
Title