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Tdark
PHTF1
Putative homeodomain transcription factor 1

Protein Summary
Description
May play a role in transcription regulation.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000357783
  • ENSP00000350428
  • ENSG00000116793
  • ENST00000369604
  • ENSP00000358617
  • ENST00000393357
  • ENSP00000377025

Symbol
  • PHTF
  • PHTF
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.96
disease perturbation
0.9
histone modification site profile
0.88
virus perturbation
0.83
tissue sample
0.71


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.54   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 28   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.54   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 28   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (31)
PHTF2
Tdark
Novelty:  0.52825058
p_int:  0.999986664
p_ni:  4e-9
p_wrong:  0.000013332
Data Source:  BioPlex
CAPN5
Tbio
Novelty:  0.02614694
p_int:  0.99800849
p_ni:  0.000006058
p_wrong:  0.001985452
Score:  0.485
Data Source:  BioPlex,STRINGDB
GPR156
Tdark
Family:  GPCR
Novelty:  0.39183023
p_int:  0.991766313
p_ni:  2.66e-7
p_wrong:  0.008233422
Data Source:  BioPlex
LYPD3
Tbio
Novelty:  0.03248533
p_int:  0.880004285
p_ni:  0.000001008
p_wrong:  0.119994707
Score:  0.344
Data Source:  BioPlex,STRINGDB
RSBN1
Tbio
Novelty:  0.1955858
Score:  0.692
Data Source:  STRINGDB
TRPV5
Tchem
Family:  IC
Novelty:  0.0055156
Score:  0.664
Data Source:  STRINGDB
NOX3
Tbio
Family:  Enzyme
Novelty:  0.01350666
Score:  0.659
Data Source:  STRINGDB
DDX1
Tchem
Family:  Enzyme
Novelty:  0.01691884
Score:  0.654
Data Source:  STRINGDB
BCL2L15
Tbio
Novelty:  0.11260258
Score:  0.621
Data Source:  STRINGDB
ACP7
Tdark
Family:  Enzyme
Novelty:  0.05718825
Score:  0.621
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (41)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
15
3
4
1.7
99.1
type 2 diabetes mellitus
2
2
0
1.5
97.3
type 1 diabetes mellitus
6
2
1
1.9
97.2
5
2
2
1.3
96.7
3
2
1
1.3
95.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
1.7
99.1
type 2 diabetes mellitus
0
1.5
97.3
type 1 diabetes mellitus
1
1.9
97.2
2
1.3
96.7
1
1.3
95.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
putative homeodomain transcription factor 1
457134
Macaque
putative homeodomain transcription factor 1
707208
Mouse
MGI:1332671
18685
Rat
RGD:620426
252962
Dog
putative homeodomain transcription factor 1
VGNC:54340
100856289
Species
Name
OMA
EggNOG
Inparanoid
Chimp
putative homeodomain transcription factor 1
Macaque
putative homeodomain transcription factor 1
Mouse
Rat
Dog
putative homeodomain transcription factor 1
Publication Statistics
PubMed Score 19.54
PubMed score by year
PubTator Score 4.31
PubTator score by year
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Related Publications
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PMID
Year
Title