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Tbio
PHRF1
PHD and RING finger domain-containing protein 1

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264555
  • ENSP00000264555
  • ENSG00000070047
  • ENST00000416188
  • ENSP00000410626
  • ENST00000534320
  • ENSP00000435360
  • ENST00000616346
  • ENSP00000483129
  • ENSG00000274780

Symbol
  • KIAA1542
  • RNF221
  • PPP1R125
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
ligand (protein) perturbation
0.83
cell line
0.74
transcription factor
0.67
phenotype
0.66


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.98   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 17   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.98   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 17   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (41)
JMJD6
Tchem
Family:  Enzyme
Novelty:  0.00305479
p_int:  0.99999998
p_ni:  6e-9
p_wrong:  1.4e-8
Score:  0.177
Data Source:  BioPlex,STRINGDB
CSNK2A2
Tchem
Family:  Kinase
Novelty:  0.00231447
p_int:  0.999999695
p_ni:  3.05e-7
Score:  0.237
Data Source:  BioPlex,STRINGDB
CSNK2B
Tbio
Family:  Kinase
Novelty:  0.00152367
p_int:  0.999999161
p_ni:  8.39e-7
Data Source:  BioPlex
POLR2J
Tbio
Family:  Enzyme
Novelty:  0.02344868
p_int:  0.999830001
p_ni:  0.000138083
p_wrong:  0.000031917
Data Source:  BioPlex
SAP18
Tbio
Family:  Enzyme
Novelty:  0.03918373
p_int:  0.99974563
p_ni:  0.00012802
p_wrong:  0.00012635
Data Source:  BioPlex
PXK
Tbio
Family:  Kinase
Novelty:  0.02316511
Score:  0.711
Data Source:  STRINGDB
FAM167A
Tbio
Novelty:  0.05232679
Score:  0.669
Data Source:  STRINGDB
BANK1
Tbio
Novelty:  0.02712029
Score:  0.669
Data Source:  STRINGDB
TRDMT1
Tbio
Family:  Enzyme
Novelty:  0.00712649
Score:  0.637
Data Source:  STRINGDB
DNMT1
Tclin
Family:  Enzyme
Novelty:  0.00042336
Score:  0.576
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (12)
Items per page:
1 – 5 of 12
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
8
7
0
1.2
91.3
8
7
0
1.2
91.3
reticulocyte measurement
2
2
2
64.4
reticulocyte measurement
2
2
2
64.4
2
2
0
1.2
46.9
Items per page:
1 – 5 of 12
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.2
91.3
0
1.2
91.3
reticulocyte measurement
2
64.4
reticulocyte measurement
2
64.4
0
1.2
46.9
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
PHD and ring finger domains 1
VGNC:50563
450926
Macaque
PHD and ring finger domains 1
699324
Mouse
MGI:2141847
101471
Rat
RGD:708360
245925
Dog
PHD and ring finger domains 1
VGNC:44510
483405
Species
Name
OMA
EggNOG
Inparanoid
Chimp
PHD and ring finger domains 1
Macaque
PHD and ring finger domains 1
Mouse
Rat
Dog
PHD and ring finger domains 1
Publication Statistics
PubMed Score 13.98
PubMed score by year
PubTator Score 3.13
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title