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Tbio
PHPT1
14 kDa phosphohistidine phosphatase

Protein Summary
Description
Exhibits phosphohistidine phosphatase activity. This gene encodes an enzyme that catalyzes the reversible dephosphorylation of histidine residues in proteins. It may be involved in the dephosphorylation of G-beta and ATP citrate lyase and in negatively regulating CD4 T lymphocytes by dephosphorylation and inhibition of KCa3.1 channels. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000247665
  • ENSP00000247665
  • ENSG00000054148
  • ENST00000371661
  • ENSP00000360724

Symbol
  • PHP14
  • PHP
  • PHP14
  • CGI-202
  • HSPC141
  • HEL-S-132P
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.77
cell type or tissue
0.74
transcription factor binding site profile
0.74
transcription factor perturbation
0.74
small molecule perturbation
0.73


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 46.92   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 328   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 46.92   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 328   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (60)
GTF2E2
Tbio
Novelty:  0.18033153
p_int:  0.999650368
p_ni:  0.00004831
p_wrong:  0.000301321
Score:  0.188
Data Source:  BioPlex,STRINGDB
NUDT9
Tbio
Family:  Enzyme
Novelty:  0.0482661
Score:  0.871
Data Source:  STRINGDB
KCNN4
Tchem
Family:  IC
Novelty:  0.00244935
Score:  0.867
Data Source:  STRINGDB
NDUFS8
Tclin
Family:  Enzyme
Novelty:  0.02408724
Score:  0.864
Data Source:  STRINGDB
UQCR11
Tbio
Novelty:  0.08583842
Score:  0.863
Data Source:  STRINGDB
NDUFB7
Tclin
Family:  Enzyme
Novelty:  0.14580093
Score:  0.848
Data Source:  STRINGDB
ATP5ME
Tbio
Family:  Enzyme
Novelty:  0.12559724
Score:  0.845
Data Source:  STRINGDB
NDUFS7
Tclin
Family:  Enzyme
Novelty:  0.01562198
Score:  0.844
Data Source:  STRINGDB
CLPP
Tchem
Family:  Enzyme
Novelty:  0.00105289
Score:  0.841
Data Source:  STRINGDB
ROMO1
Tbio
Novelty:  0.01909602
Score:  0.835
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
1
1
1
47.7
heel bone mineral density
1
1
1
28.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
1
47.7
heel bone mineral density
1
28.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1922704
75454
Rat
RGD:1311355
296571
Dog
phosphohistidine phosphatase 1
VGNC:44509
491245
Cow
phosphohistidine phosphatase 1
VGNC:32846
618691
Opossum
phosphohistidine phosphatase 1
100017116
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
phosphohistidine phosphatase 1
Cow
phosphohistidine phosphatase 1
Opossum
phosphohistidine phosphatase 1
Publication Statistics
PubMed Score 46.92
PubMed score by year
PubTator Score 48.99
PubTator score by year
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Related Publications
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PMID
Year
Title